Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Association of Changes in Inflammation with Changes in Glycemia, Insulin Resistance and Secretion: a DIRECT study based on KORA

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Diabetes i familien – familien og diabetes

    Research output: Contribution to journalContribution to newspaper - Comment/debateCommunication

  2. Diabetespatienter er afhængige af et løft af det nære sundhedsvæsen

    Research output: Other contributionNet publication - Internet publicationCommunication

  3. Forord

    Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

  4. Kun gode relationer kan nedbryde ’Sundhedsvæsnets Bermudatrekant’

    Research output: Contribution to journalContribution to newspaper - Comment/debateCommunication

  5. Low serum adiponectin is associated with the metabolic syndrome and adds to cardiovascular risk in individuals with type 1 diabetes without nephropathy

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  • Tonia de Las Heras Gala
  • Christian Herder
  • Femke Rutters
  • Maren Carstensen-Kirberg
  • Cornelia Huth
  • Coen D A Stehouwer
  • Giel Nijpels
  • Casper Schalkwijk
  • Allan Flyvbjerg
  • Paul W Franks
  • Jacqueline Dekker
  • Christa Meisinger
  • Wolfgang Koenig
  • Michael Roden
  • Wolfgang Rathmann
  • Annette Peters
  • Barbara Thorand
View graph of relations

AIMS: Subclinical systemic inflammation may contribute to the development of type 2 diabetes, but its association with early progression of glycemic deterioration in persons without diabetes has not been fully investigated. Our primary aim was to assess longitudinal associations of changes in pro- (leukocytes, high-sensitivity C-reactive protein (hsCRP)) and anti-inflammatory (adiponectin) markers with changes in markers that assessed glycemia, insulin resistance and secretion (HbA1c , HOMA-IR, HOMA-ß). Furthermore, we aimed to directly compare longitudinal with cross-sectional associations.

MATERIALS AND METHODS: This study includes 819 initially non-diabetic individuals with repeated measurements from the KORA S4/F4 cohort study (median follow-up: 7.1 years). Longitudinal and cross-sectional associations were simultaneously examined using linear mixed growth models. Changes in markers of inflammation were used as independent and changes in markers of glycemia/insulin resistance/insulin secretion as dependent variables. Models were adjusted for age, sex and major lifestyle and metabolic risk factors for diabetes using time-varying variables in the final model.

RESULTS: Changes of leukocyte count were positively associated with changes in HbA1c and HOMA-ß while changes in adiponectin were inversely associated with changes in HbA1c . All examined cross-sectional associations were statistically significant; they were generally stronger and mostly directionally consistent to the longitudinal association estimates.

CONCLUSIONS: Adverse changes in low-grade systemic inflammation go along with glycemic deterioration and increased insulin secretion independently of changes in other risk factors, suggesting that low-grade inflammation may contribute to the development of hyperglycemia and a compensatory increase in insulin secretion.

Original languageEnglish
JournalDiabetes - Metabolism: Research and Reviews (Online)
Volume34
Issue number8
Pages (from-to)e3063
ISSN1520-7560
DOIs
Publication statusPublished - Nov 2018

ID: 55046079