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Association between vascular inflammation and inflammation in adipose tissue, spleen, and bone marrow in patients with psoriasis

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@article{2637304e81294958aa705901c4d6cb34,
title = "Association between vascular inflammation and inflammation in adipose tissue, spleen, and bone marrow in patients with psoriasis",
abstract = "Psoriasis is associated with atherosclerotic cardiovascular disease (CVD) with significant overlap of inflammatory pathways. A link between vascular inflammation and inflammation in multiple adipose tissue types, spleen, and bone marrow may exist. Therefore, we investigated these associations using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) in patients with psoriasis (n = 83) where half had established CVD. Carotid ultrasound imaging was also performed. Inflammation was measured by FDG uptake in the aorta, visceral- (VAT), subcutaneous- (SAT), and pericardial (PAT) adipose tissues, and spleen and bone marrow, respectively. Vascular inflammation was associated with FDG uptakes in all adipose tissues, including VAT (β = 0.26; p < 0.001), SAT (β = 0.28; p < 0.001), PAT (β = 0.24; p < 0.001), spleen (β = 1.35; p = 0.001), and bone marrow (β = 1.14; p < 0.001). Adjustments for age, sex, body mass index, and high sensitivity C-reactive protein did not change the results. These associations were generally preserved in the patients without prior CVD. No associations were observed between vascular inflammation and carotid intima-media thickness or presence of carotid plaques, respectively. The results suggest an inflammatory link between vascular and adipose tissues, spleen, and bone marrow in patients with psoriasis.",
keywords = "F-FDG-PET/CT, Adipose tissue, Cardiovascular disease, Psoriasis, Vascular inflammation, CT, cardiovascular disease, F-18-FDG-PET, psoriasis, adipose tissue, vascular inflammation",
author = "Hannah Kaiser and Amanda Kvist-Hansen and Martin Krakauer and G{\o}rtz, {Peter Michael} and Henningsen, {Kristoffer Mads Aaris} and Xing Wang and Christine Becker and Claus Zachariae and Lone Skov and Hansen, {Peter Riis}",
note = "Funding Information: Funding: The study is supported by the LEO Foundation (grant no. LF16115). Funding Information: Conflicts of Interest: P.R.H. is recipient of a Borregaard clinical scientist fellowship from the NOVO Nordisk Foundation and chairs a clinical academic group supported by the Greater Region of Copenhagen. C.B. is a consultant for Onegevity Health. L.S. has been a paid speaker for AbbVie, Eli Lilly, and LEO Pharma and has been a consultant or served on Advisory Boards with AbbVie, Janssen Cilag, Novartis, Eli Lilly, LEO Pharma, UCB, Admirall, and Sanofi. She has served as an investigator for AbbVie, Janssen Cilag, Boehringer Ingelheim, AstraZenica, Eli Lilly, Novartis, Regeneron, and LEO Pharma and received research and educational grant from Pfizer, AbbVie, Novartis, Sanofi, Janssen Cilag, and Leo Pharma. C.Z. has been scientific consultant, advisor, investigator and speaker for Eli Lilly, Jansen Cilag, Novartis, Abb Vie, Takeda, Amgen, Almirall, CSL, UCB, Regeneron, MSD, and Leo Pharma. H.K., A.K.H., M.K., P.M.G., K.M.A.H., XW declare that they have no competing interests. Publisher Copyright: {\textcopyright} 2021 by the authors. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = apr,
day = "1",
doi = "10.3390/life11040305",
language = "English",
volume = "11",
journal = "Life",
issn = "2075-1729",
publisher = "MDPI Multidisciplinary Digital Publishing Institute",
number = "4",

}

RIS

TY - JOUR

T1 - Association between vascular inflammation and inflammation in adipose tissue, spleen, and bone marrow in patients with psoriasis

AU - Kaiser, Hannah

AU - Kvist-Hansen, Amanda

AU - Krakauer, Martin

AU - Gørtz, Peter Michael

AU - Henningsen, Kristoffer Mads Aaris

AU - Wang, Xing

AU - Becker, Christine

AU - Zachariae, Claus

AU - Skov, Lone

AU - Hansen, Peter Riis

N1 - Funding Information: Funding: The study is supported by the LEO Foundation (grant no. LF16115). Funding Information: Conflicts of Interest: P.R.H. is recipient of a Borregaard clinical scientist fellowship from the NOVO Nordisk Foundation and chairs a clinical academic group supported by the Greater Region of Copenhagen. C.B. is a consultant for Onegevity Health. L.S. has been a paid speaker for AbbVie, Eli Lilly, and LEO Pharma and has been a consultant or served on Advisory Boards with AbbVie, Janssen Cilag, Novartis, Eli Lilly, LEO Pharma, UCB, Admirall, and Sanofi. She has served as an investigator for AbbVie, Janssen Cilag, Boehringer Ingelheim, AstraZenica, Eli Lilly, Novartis, Regeneron, and LEO Pharma and received research and educational grant from Pfizer, AbbVie, Novartis, Sanofi, Janssen Cilag, and Leo Pharma. C.Z. has been scientific consultant, advisor, investigator and speaker for Eli Lilly, Jansen Cilag, Novartis, Abb Vie, Takeda, Amgen, Almirall, CSL, UCB, Regeneron, MSD, and Leo Pharma. H.K., A.K.H., M.K., P.M.G., K.M.A.H., XW declare that they have no competing interests. Publisher Copyright: © 2021 by the authors. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/4/1

Y1 - 2021/4/1

N2 - Psoriasis is associated with atherosclerotic cardiovascular disease (CVD) with significant overlap of inflammatory pathways. A link between vascular inflammation and inflammation in multiple adipose tissue types, spleen, and bone marrow may exist. Therefore, we investigated these associations using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) in patients with psoriasis (n = 83) where half had established CVD. Carotid ultrasound imaging was also performed. Inflammation was measured by FDG uptake in the aorta, visceral- (VAT), subcutaneous- (SAT), and pericardial (PAT) adipose tissues, and spleen and bone marrow, respectively. Vascular inflammation was associated with FDG uptakes in all adipose tissues, including VAT (β = 0.26; p < 0.001), SAT (β = 0.28; p < 0.001), PAT (β = 0.24; p < 0.001), spleen (β = 1.35; p = 0.001), and bone marrow (β = 1.14; p < 0.001). Adjustments for age, sex, body mass index, and high sensitivity C-reactive protein did not change the results. These associations were generally preserved in the patients without prior CVD. No associations were observed between vascular inflammation and carotid intima-media thickness or presence of carotid plaques, respectively. The results suggest an inflammatory link between vascular and adipose tissues, spleen, and bone marrow in patients with psoriasis.

AB - Psoriasis is associated with atherosclerotic cardiovascular disease (CVD) with significant overlap of inflammatory pathways. A link between vascular inflammation and inflammation in multiple adipose tissue types, spleen, and bone marrow may exist. Therefore, we investigated these associations using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) in patients with psoriasis (n = 83) where half had established CVD. Carotid ultrasound imaging was also performed. Inflammation was measured by FDG uptake in the aorta, visceral- (VAT), subcutaneous- (SAT), and pericardial (PAT) adipose tissues, and spleen and bone marrow, respectively. Vascular inflammation was associated with FDG uptakes in all adipose tissues, including VAT (β = 0.26; p < 0.001), SAT (β = 0.28; p < 0.001), PAT (β = 0.24; p < 0.001), spleen (β = 1.35; p = 0.001), and bone marrow (β = 1.14; p < 0.001). Adjustments for age, sex, body mass index, and high sensitivity C-reactive protein did not change the results. These associations were generally preserved in the patients without prior CVD. No associations were observed between vascular inflammation and carotid intima-media thickness or presence of carotid plaques, respectively. The results suggest an inflammatory link between vascular and adipose tissues, spleen, and bone marrow in patients with psoriasis.

KW - F-FDG-PET/CT

KW - Adipose tissue

KW - Cardiovascular disease

KW - Psoriasis

KW - Vascular inflammation

KW - CT

KW - cardiovascular disease

KW - F-18-FDG-PET

KW - psoriasis

KW - adipose tissue

KW - vascular inflammation

UR - http://www.scopus.com/inward/record.url?scp=85104063153&partnerID=8YFLogxK

U2 - 10.3390/life11040305

DO - 10.3390/life11040305

M3 - Journal article

C2 - 33915972

AN - SCOPUS:85104063153

VL - 11

JO - Life

JF - Life

SN - 2075-1729

IS - 4

M1 - 305

ER -

ID: 66081278