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Association between TSH-Receptor Autoimmunity, Hyperthyroidism, Goitre, and Orbitopathy in 208 Patients Included in the Remission Induction and Sustenance in Graves' Disease Study

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DOI

  1. Predictors of Initial and Sustained Remission in Patients Treated with Antithyroid Drugs for Graves' Hyperthyroidism: The RISG Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Corrigendum to "Challenges in Interpretation of Thyroid Function Tests in Pregnant Women with Autoimmune Thyroid Disease"

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  3. Challenges in interpretation of thyroid function tests in pregnant women with autoimmune thyroid disease

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  4. Do Thyroid Disrupting Chemicals Influence Foetal Development during Pregnancy?

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  1. Predictors of Initial and Sustained Remission in Patients Treated with Antithyroid Drugs for Graves' Hyperthyroidism: The RISG Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Association between 3-Iodothyronamine (T1AM) Concentrations and Left Ventricular Function in Chronic Heart Failure

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  3. Levothyroxine/Liothyronine Combination Therapy and Quality of Life: Is It All about Weight Loss?

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  4. Kombinationsbehandling med thyroxin og trijodthyronin til patienter med hypotyreose

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  • Peter Laurberg
  • Birte Nygaard
  • Stig Andersen
  • Allan Carlé
  • Jesper Scott Karmisholt
  • Anne Krejbjerg
  • Inge Bülow Pedersen
  • Stine Linding Andersen
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Background. Graves' disease may have a number of clinical manifestations with varying degrees of activity that may not always run in parallel. Objectives. To study associations between serum levels of TSH-receptor autoantibodies and the three main manifestations of Graves' disease (hyperthyroidism, goiter, and presence of orbitopathy) at the time of diagnosis of hyperthyroidism. Methods. We describe a cohort of 208 patients with newly diagnosed Graves' hyperthyroidism. Patients were enrolled in a multiphase study of antithyroid drug therapy of Graves' hyperthyroidism, entitled "Remission Induction and Sustenance in Graves' Disease (RISG)." Patients were systematically tested for degree of biochemical hyperthyroidism, enlarged thyroid volume by ultrasonography, and the presence of orbitopathy. Results. Positive correlations were found between the levels of TSH-receptor autoantibodies in serum and the three manifestations of Graves' disease: severeness of hyperthyroidism, presence of enlarged thyroid, and presence of orbitopathy, as well as between the different types of manifestations. Only around half of patients had enlarged thyroid gland at the time of diagnosis of hyperthyroidism, whereas 25-30% had orbitopathy. Conclusions. A positive but rather weak correlation was found between TSH-receptor antibodies in serum and the major clinical manifestation of Graves' disease. Only half of the patients had an enlarged thyroid gland at the time of diagnosis.

Original languageEnglish
JournalJournal of Thyroid Research
Volume2014
Pages (from-to)165487
ISSN2042-0072
DOIs
Publication statusPublished - 2014

ID: 44378062