Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Association between plasma apolipoprotein M and cardiac autonomic neuropathy in type 1 diabetes

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Baseline risk markers and visit-to-visit variability in relation to kidney outcomes - A post-hoc analysis of the PERL study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Severe mental illness and quality of care for type 2 diabetes: A retrospective population-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Blood Pressure and Cardiorenal Outcomes With Finerenone in Chronic Kidney Disease in Type 2 Diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Diagnostic and prognostic value of the electrocardiogram in stable outpatients with type 2 diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

AIM: Diabetes may lead to severe complications e.g. cardiac autonomic neuropathy (CAN) characterized by an increased risk of cardiovascular mortality. CAN is diagnosed by a decreased heart rate viability (HRV). Sphingosine-1-Phosphate (S1P) carried by the HDL-associated apolipoprotein M (apoM) is linked to a reduction in the heart rate, and treatment with an S1P-agonist increases HRV. The present study aimed to investigate if plasma apoM was associated with an increased risk of CAN.

METHODS: The study includes 278 individuals with Type 1 Diabetes recruited from Steno Diabetes Center in Copenhagen from 2010 to 2012.

RESULTS: A change of 0.1 µM plasma apoM was associated with the diagnosis of CAN (Odds ratio: 1.11 (1.02; 1.21), p=0.013). ApoM plasma levels were also positively associated with CAN when adjusted for age and gender (Odds ratio: 1.11 (1.02;1.21), p=0.013) as well as lipids, beta-blockers, blood pressure, and alcohol (Odds ratio: 1.14 (1.04; 1.26), p=0.005) and Hbga1c and time with diabetes (Odds ratio: 1.13 (1.02; 1.25), p=0.01). Plasma apoM was also associated with a significantly lower SDNN as well as high frequency power in all adjusted models.

CONCLUSION: Increased plasma apoM was associated with an increased risk of CAN as well as a significant reduction in HRV indices. This could represent changes in parasympathetic activity, but, further studies are needed to also explore additional molecular alterations behind such observations.

Original languageEnglish
Article number109943
JournalDiabetes Research and Clinical Practice
Volume189
ISSN0168-8227
DOIs
Publication statusPublished - Jul 2022

Bibliographical note

Copyright © 2022. Published by Elsevier B.V.

    Research areas

  • Apolipoprotein M, Cardiac autonomic neuropathy, Sphingosine-1-phosphate

ID: 78739481