Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Association between neurovascular contact and clinical characteristics in classical trigeminal neuralgia: A prospective clinical study using 3.0 Tesla MRI

Research output: Contribution to journalJournal articlepeer-review

DOI

  1. Effect of KATP channel blocker glibenclamide on PACAP38-induced headache and hemodynamic

    Research output: Contribution to journalJournal articlepeer-review

  2. Involvement of adenosine signaling pathway in migraine pathophysiology: A systematic review of clinical studies

    Research output: Contribution to journalJournal articlepeer-review

  3. Headache provocation by nitric oxide in men who have never experienced a headache

    Research output: Contribution to journalJournal articlepeer-review

View graph of relations

BACKGROUND: Previous studies demonstrated that a severe neurovascular contact (NVC) causing displacement or atrophy of the trigeminal nerve is highly associated with classical trigeminal neuralgia (TN). There are no studies describing the association between the clinical characteristics of TN and severe NVC.

METHODS: Clinical characteristics were prospectively collected from consecutive TN patients using semi-structured interviews in a cross-sectional study design. We evaluated 3.0 Tesla MRI blinded to the symptomatic side.

RESULTS: We included 135 TN patients. Severe NVC was more prevalent in men (75%) compared to women (38%) (p < 0.001), and the odds in favor of severe NVC on the symptomatic side were 5.1 times higher in men compared to women (95% CI 2.3-10.9, p < 0.001). There was no difference between patients with and without severe NVC in age (≥60 years vs. <60) (OR 1.6 95% CI (0.8-3.4), p = 0.199) or duration of disease (p = 0.101).

CONCLUSIONS: Severe NVC was much more prevalent in men than in women, who may more often have other disease etiologies causing or contributing to TN. Severe NVC was not associated with age or with duration of disease.

Original languageEnglish
JournalCephalalgia : an international journal of headache
Volume35
Issue number12
Pages (from-to)1077-84
ISSN0333-1024
DOIs
Publication statusPublished - 23 Jan 2015

ID: 45512364