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Association between Neonatal Whole Blood Iron Content and Cytokines, Adipokines, and Other Immune Response Proteins

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@article{ef20a52bb6df4af288768e090d56df6b,
title = "Association between Neonatal Whole Blood Iron Content and Cytokines, Adipokines, and Other Immune Response Proteins",
abstract = "(1) Background: High iron associates with inflammation and type 1 diabetes (T1D). Iron is essential not only for neonatal development but also for infectious microorganisms. The neonatal immune system is immature, and innate immunity prevails before immunocompetence develops. (2) Methods: In 398 newborns from the Danish Newborn Screening Biobank, we examined if whole blood iron (WB-Iron) content were associated with cytokines, adipokines, C-reactive protein (CRP), and mannose-binding lectin (MBL) in non-infected healthy neonates, and if these associations differed in newborns who later developed T1D (cases) (n = 199). WB-Iron was quantified using laser ablation inductively coupled plasma mass spectrometry on the neonatal dried blood spots. For each analyte, the relative change (RC) in the mean level was modeled by robust log-normal regression. (3) Results: A one unit increase in neonatal WB-Iron was associated with a 38{\%} decrease in mean interleukin (IL)-6 levels (0.62; 95{\%} CI: 0.40⁻0.95, p = 0.03), and a 37{\%} decrease in mean MBL levels (0.63; 95{\%} CI: 0.41⁻0.95, p = 0.03), but was not statistically significant after correction for multiple testing. (4) Conclusions: In summary, we found that higher neonatal WB-iron content was inversely associated with IL-6 and MBL, which may increase susceptibility to infections.",
keywords = "Adipokines, C-reactive protein, Cytokines, Diabetes mellitus, Human, Infant, Iron, Mannose-binding lectin, Newborn, TREM1, Type 1",
author = "Thorsen, {Steffen U} and Pipper, {Christian B} and Christina Ellervik and Flemming Pociot and Kyvsgaard, {Julie N} and Jannet Svensson",
year = "2019",
month = "3",
day = "1",
doi = "10.3390/nu11030543",
language = "English",
volume = "11",
journal = "Nutrients",
issn = "2072-6643",
publisher = "M D P I AG",
number = "3",

}

RIS

TY - JOUR

T1 - Association between Neonatal Whole Blood Iron Content and Cytokines, Adipokines, and Other Immune Response Proteins

AU - Thorsen, Steffen U

AU - Pipper, Christian B

AU - Ellervik, Christina

AU - Pociot, Flemming

AU - Kyvsgaard, Julie N

AU - Svensson, Jannet

PY - 2019/3/1

Y1 - 2019/3/1

N2 - (1) Background: High iron associates with inflammation and type 1 diabetes (T1D). Iron is essential not only for neonatal development but also for infectious microorganisms. The neonatal immune system is immature, and innate immunity prevails before immunocompetence develops. (2) Methods: In 398 newborns from the Danish Newborn Screening Biobank, we examined if whole blood iron (WB-Iron) content were associated with cytokines, adipokines, C-reactive protein (CRP), and mannose-binding lectin (MBL) in non-infected healthy neonates, and if these associations differed in newborns who later developed T1D (cases) (n = 199). WB-Iron was quantified using laser ablation inductively coupled plasma mass spectrometry on the neonatal dried blood spots. For each analyte, the relative change (RC) in the mean level was modeled by robust log-normal regression. (3) Results: A one unit increase in neonatal WB-Iron was associated with a 38% decrease in mean interleukin (IL)-6 levels (0.62; 95% CI: 0.40⁻0.95, p = 0.03), and a 37% decrease in mean MBL levels (0.63; 95% CI: 0.41⁻0.95, p = 0.03), but was not statistically significant after correction for multiple testing. (4) Conclusions: In summary, we found that higher neonatal WB-iron content was inversely associated with IL-6 and MBL, which may increase susceptibility to infections.

AB - (1) Background: High iron associates with inflammation and type 1 diabetes (T1D). Iron is essential not only for neonatal development but also for infectious microorganisms. The neonatal immune system is immature, and innate immunity prevails before immunocompetence develops. (2) Methods: In 398 newborns from the Danish Newborn Screening Biobank, we examined if whole blood iron (WB-Iron) content were associated with cytokines, adipokines, C-reactive protein (CRP), and mannose-binding lectin (MBL) in non-infected healthy neonates, and if these associations differed in newborns who later developed T1D (cases) (n = 199). WB-Iron was quantified using laser ablation inductively coupled plasma mass spectrometry on the neonatal dried blood spots. For each analyte, the relative change (RC) in the mean level was modeled by robust log-normal regression. (3) Results: A one unit increase in neonatal WB-Iron was associated with a 38% decrease in mean interleukin (IL)-6 levels (0.62; 95% CI: 0.40⁻0.95, p = 0.03), and a 37% decrease in mean MBL levels (0.63; 95% CI: 0.41⁻0.95, p = 0.03), but was not statistically significant after correction for multiple testing. (4) Conclusions: In summary, we found that higher neonatal WB-iron content was inversely associated with IL-6 and MBL, which may increase susceptibility to infections.

KW - Adipokines

KW - C-reactive protein

KW - Cytokines

KW - Diabetes mellitus

KW - Human

KW - Infant

KW - Iron

KW - Mannose-binding lectin

KW - Newborn

KW - TREM1

KW - Type 1

UR - http://www.scopus.com/inward/record.url?scp=85062601244&partnerID=8YFLogxK

U2 - 10.3390/nu11030543

DO - 10.3390/nu11030543

M3 - Journal article

VL - 11

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 3

M1 - 543

ER -

ID: 56845742