Association between MRI findings and patient-reported outcomes in patients with rheumatoid arthritis in clinical remission and at relapse

Daniel Glinatsi; Cecilie H Brahe; Merete L Hetland; Lykke Ørnbjerg; Simon Krabbe; Joshua F Baker; Mikael Boesen; Zoreh Rastiemadabadi; Lone Morsel-Carlsen; Henrik Røgind; Annette Hansen; Jesper Nørregaard; Søren Jacobsen; Lene Terslev; Tuan K Huynh; Natalia Manilo; Dorte V Jensen; Jakob M Møller; Niels S Krogh; Mikkel Østergaard

doi:10.1111/1756-185X.13790

Association between MRI findings and patient-reported outcomes in patients with rheumatoid arthritis in clinical remission and at relapse

Daniel Glinatsi, Cecilie H Brahe, Merete L Hetland, Lykke Ørnbjerg, Simon Krabbe, Joshua F Baker, Mikael Boesen, Zoreh Rastiemadabadi, Lone Morsel-Carlsen, Henrik Røgind, Annette Hansen, Jesper Nørregaard, Søren Jacobsen, Lene Terslev, Tuan K Huynh, Natalia Manilo, Dorte V Jensen, Jakob M Møller, Niels S Krogh, Mikkel Østergaard

Abstract

OBJECTIVE: To investigate whether magnetic resonance imaging (MRI) pathologies in the wrist/hand of rheumatoid arthritis (RA) patients are associated with patient-reported outcomes (PROs) at clinical remission and relapse.

METHODS: Wrist/hand MRIs and wrists/hands/feet radiographs were obtained in 114 established RA patients in clinical remission, before tapering their biologic disease-modifying antirheumatic drugs. MRIs were assessed according to the Outcome Measures in Rheumatology (OMERACT) RA MRI score (RAMRIS) for inflammation (synovitis/tenosynovitis/bone marrow edema) and damage (bone erosion/joint space narrowing) at baseline (ie remission) and in case of a relapse (n = 70). Radiographs were assessed according to the Sharp/van der Heijde (SvH) method at baseline. These scores were assessed for associations with health assessment questionnaires (HAQ), visual analog scales (VAS global/pain), EuroQol-5 dimensions and Short-Form 36 physical and mental component summary (SF-36 PCS/MCS) using Spearman correlations, univariate/multivariable linear regression analyses and generalized estimating equations. Furthermore, MRI pathologies were assessed for association with specific hand-related HAQ items using Jonckheere trend tests.

RESULTS: Magnetic resonance imaging-assessed damage was associated with impaired HAQ and SF-36 PCS at remission and relapse (P < .01), independent of clinical and radiographic measures, and was also associated with most of the hand-related HAQ items (P < .03). In multivariate models including MRI, SvH scores were not associated with PROs. MRI-assessed inflammation was not associated with PROs at remission or relapse.

CONCLUSION: Magnetic resonance imaging-assessed wrist/hand damage, but not inflammation, in patients with established RA is associated with patient-reported physical impairment at remission and relapse. The amount of damage in the wrist/hand is associated with reduced hand function.

Original language	English
Journal	International Journal of Rheumatic Diseases
Volume	23
Issue number	4
Pages (from-to)	488-498
Number of pages	10
ISSN	1756-1841
DOIs	https://doi.org/10.1111/1756-185X.13790
Publication status	Published - Apr 2020

Keywords

hand
magnetic resonance imaging
rheumatoid arthritis

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10.1111/1756-185X.13790

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Glinatsi, D., Brahe, C. H., Hetland, M. L., Ørnbjerg, L., Krabbe, S., Baker, J. F., Boesen, M., Rastiemadabadi, Z., Morsel-Carlsen, L., Røgind, H., Hansen, A., Nørregaard, J., Jacobsen, S., Terslev, L., Huynh, T. K., Manilo, N., Jensen, D. V., Møller, J. M., Krogh, N. S., & Østergaard, M. (2020). Association between MRI findings and patient-reported outcomes in patients with rheumatoid arthritis in clinical remission and at relapse. International Journal of Rheumatic Diseases, 23(4), 488-498. https://doi.org/10.1111/1756-185X.13790

Association between MRI findings and patient-reported outcomes in patients with rheumatoid arthritis in clinical remission and at relapse. / Glinatsi, Daniel ; Brahe, Cecilie H ; Hetland, Merete L et al.
In: International Journal of Rheumatic Diseases, Vol. 23, No. 4, 04.2020, p. 488-498.

Research output: Contribution to journal › Journal article › Research › peer-review

Glinatsi, D , Brahe, CH , Hetland, ML , Ørnbjerg, L , Krabbe, S, Baker, JF, Boesen, M, Rastiemadabadi, Z, Morsel-Carlsen, L , Røgind, H , Hansen, A , Nørregaard, J , Jacobsen, S , Terslev, L, Huynh, TK, Manilo, N , Jensen, DV , Møller, JM, Krogh, NS & Østergaard, M 2020, 'Association between MRI findings and patient-reported outcomes in patients with rheumatoid arthritis in clinical remission and at relapse', International Journal of Rheumatic Diseases, vol. 23, no. 4, pp. 488-498. https://doi.org/10.1111/1756-185X.13790

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title = "Association between MRI findings and patient-reported outcomes in patients with rheumatoid arthritis in clinical remission and at relapse",

abstract = "OBJECTIVE: To investigate whether magnetic resonance imaging (MRI) pathologies in the wrist/hand of rheumatoid arthritis (RA) patients are associated with patient-reported outcomes (PROs) at clinical remission and relapse.METHODS: Wrist/hand MRIs and wrists/hands/feet radiographs were obtained in 114 established RA patients in clinical remission, before tapering their biologic disease-modifying antirheumatic drugs. MRIs were assessed according to the Outcome Measures in Rheumatology (OMERACT) RA MRI score (RAMRIS) for inflammation (synovitis/tenosynovitis/bone marrow edema) and damage (bone erosion/joint space narrowing) at baseline (ie remission) and in case of a relapse (n = 70). Radiographs were assessed according to the Sharp/van der Heijde (SvH) method at baseline. These scores were assessed for associations with health assessment questionnaires (HAQ), visual analog scales (VAS global/pain), EuroQol-5 dimensions and Short-Form 36 physical and mental component summary (SF-36 PCS/MCS) using Spearman correlations, univariate/multivariable linear regression analyses and generalized estimating equations. Furthermore, MRI pathologies were assessed for association with specific hand-related HAQ items using Jonckheere trend tests.RESULTS: Magnetic resonance imaging-assessed damage was associated with impaired HAQ and SF-36 PCS at remission and relapse (P < .01), independent of clinical and radiographic measures, and was also associated with most of the hand-related HAQ items (P < .03). In multivariate models including MRI, SvH scores were not associated with PROs. MRI-assessed inflammation was not associated with PROs at remission or relapse.CONCLUSION: Magnetic resonance imaging-assessed wrist/hand damage, but not inflammation, in patients with established RA is associated with patient-reported physical impairment at remission and relapse. The amount of damage in the wrist/hand is associated with reduced hand function.",

keywords = "hand, magnetic resonance imaging, rheumatoid arthritis",

author = "Daniel Glinatsi and Brahe, {Cecilie H} and Hetland, {Merete L} and Lykke {\O}rnbjerg and Simon Krabbe and Baker, {Joshua F} and Mikael Boesen and Zoreh Rastiemadabadi and Lone Morsel-Carlsen and Henrik R{\o}gind and Annette Hansen and Jesper N{\o}rregaard and S{\o}ren Jacobsen and Lene Terslev and Huynh, {Tuan K} and Natalia Manilo and Jensen, {Dorte V} and M{\o}ller, {Jakob M} and Krogh, {Niels S} and Mikkel {\O}stergaard",

note = "COPECARE",

year = "2020",

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doi = "10.1111/1756-185X.13790",

language = "English",

volume = "23",

pages = "488--498",

journal = "International Journal of Rheumatic Diseases",

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TY - JOUR

T1 - Association between MRI findings and patient-reported outcomes in patients with rheumatoid arthritis in clinical remission and at relapse

AU - Glinatsi, Daniel

AU - Brahe, Cecilie H

AU - Hetland, Merete L

AU - Ørnbjerg, Lykke

AU - Krabbe, Simon

AU - Baker, Joshua F

AU - Boesen, Mikael

AU - Rastiemadabadi, Zoreh

AU - Morsel-Carlsen, Lone

AU - Røgind, Henrik

AU - Hansen, Annette

AU - Nørregaard, Jesper

AU - Jacobsen, Søren

AU - Terslev, Lene

AU - Huynh, Tuan K

AU - Manilo, Natalia

AU - Jensen, Dorte V

AU - Møller, Jakob M

AU - Krogh, Niels S

AU - Østergaard, Mikkel

N1 - COPECARE

PY - 2020/4

Y1 - 2020/4

N2 - OBJECTIVE: To investigate whether magnetic resonance imaging (MRI) pathologies in the wrist/hand of rheumatoid arthritis (RA) patients are associated with patient-reported outcomes (PROs) at clinical remission and relapse.METHODS: Wrist/hand MRIs and wrists/hands/feet radiographs were obtained in 114 established RA patients in clinical remission, before tapering their biologic disease-modifying antirheumatic drugs. MRIs were assessed according to the Outcome Measures in Rheumatology (OMERACT) RA MRI score (RAMRIS) for inflammation (synovitis/tenosynovitis/bone marrow edema) and damage (bone erosion/joint space narrowing) at baseline (ie remission) and in case of a relapse (n = 70). Radiographs were assessed according to the Sharp/van der Heijde (SvH) method at baseline. These scores were assessed for associations with health assessment questionnaires (HAQ), visual analog scales (VAS global/pain), EuroQol-5 dimensions and Short-Form 36 physical and mental component summary (SF-36 PCS/MCS) using Spearman correlations, univariate/multivariable linear regression analyses and generalized estimating equations. Furthermore, MRI pathologies were assessed for association with specific hand-related HAQ items using Jonckheere trend tests.RESULTS: Magnetic resonance imaging-assessed damage was associated with impaired HAQ and SF-36 PCS at remission and relapse (P < .01), independent of clinical and radiographic measures, and was also associated with most of the hand-related HAQ items (P < .03). In multivariate models including MRI, SvH scores were not associated with PROs. MRI-assessed inflammation was not associated with PROs at remission or relapse.CONCLUSION: Magnetic resonance imaging-assessed wrist/hand damage, but not inflammation, in patients with established RA is associated with patient-reported physical impairment at remission and relapse. The amount of damage in the wrist/hand is associated with reduced hand function.

AB - OBJECTIVE: To investigate whether magnetic resonance imaging (MRI) pathologies in the wrist/hand of rheumatoid arthritis (RA) patients are associated with patient-reported outcomes (PROs) at clinical remission and relapse.METHODS: Wrist/hand MRIs and wrists/hands/feet radiographs were obtained in 114 established RA patients in clinical remission, before tapering their biologic disease-modifying antirheumatic drugs. MRIs were assessed according to the Outcome Measures in Rheumatology (OMERACT) RA MRI score (RAMRIS) for inflammation (synovitis/tenosynovitis/bone marrow edema) and damage (bone erosion/joint space narrowing) at baseline (ie remission) and in case of a relapse (n = 70). Radiographs were assessed according to the Sharp/van der Heijde (SvH) method at baseline. These scores were assessed for associations with health assessment questionnaires (HAQ), visual analog scales (VAS global/pain), EuroQol-5 dimensions and Short-Form 36 physical and mental component summary (SF-36 PCS/MCS) using Spearman correlations, univariate/multivariable linear regression analyses and generalized estimating equations. Furthermore, MRI pathologies were assessed for association with specific hand-related HAQ items using Jonckheere trend tests.RESULTS: Magnetic resonance imaging-assessed damage was associated with impaired HAQ and SF-36 PCS at remission and relapse (P < .01), independent of clinical and radiographic measures, and was also associated with most of the hand-related HAQ items (P < .03). In multivariate models including MRI, SvH scores were not associated with PROs. MRI-assessed inflammation was not associated with PROs at remission or relapse.CONCLUSION: Magnetic resonance imaging-assessed wrist/hand damage, but not inflammation, in patients with established RA is associated with patient-reported physical impairment at remission and relapse. The amount of damage in the wrist/hand is associated with reduced hand function.

KW - hand

KW - magnetic resonance imaging

KW - rheumatoid arthritis

U2 - 10.1111/1756-185X.13790

DO - 10.1111/1756-185X.13790

M3 - Journal article

C2 - 31994328

SN - 1756-1841

VL - 23

SP - 488

EP - 498

JO - International Journal of Rheumatic Diseases

JF - International Journal of Rheumatic Diseases

IS - 4

ER -

Association between MRI findings and patient-reported outcomes in patients with rheumatoid arthritis in clinical remission and at relapse

Abstract

Keywords

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