Association between lectin complement pathway initiators, C-reactive protein and left ventricular remodeling in myocardial infarction-a magnetic resonance study

Mikkel Malby Schoos; Lea Munthe-Fog; Mikkel-Ole Skjoedt; Rasmus Sejersten Ripa; Jacob Lønborg; Jens Kastrup; Henning Kelbæk; Peter Clemmensen; Peter Garred

doi:10.1016/j.molimm.2013.01.008

Association between lectin complement pathway initiators, C-reactive protein and left ventricular remodeling in myocardial infarction-a magnetic resonance study

Mikkel Malby Schoos, Lea Munthe-Fog, Mikkel-Ole Skjoedt, Rasmus Sejersten Ripa, Jacob Lønborg, Jens Kastrup, Henning Kelbæk, Peter Clemmensen, Peter Garred

25 Citations (Scopus)

Abstract

Lectin complement pathway (LP) activation is an important mechanism in myocardial ischemia reperfusion injury (IRI). LP is activated via the recognition molecules mannose-binding lectin (MBL), ficolins-2 and-3 and is regulated by MBL/Ficolin-associated Protein-1 (MAP-1). Also, C-reactive protein (CRP) and ficolin-2 interact in vitro, but the role of the ficolins in IRI is unknown.

Original language	English
Journal	Cellular & Molecular Immunology
Volume	54
Issue number	3-4
Pages (from-to)	408-14
Number of pages	7
ISSN	1672-7681
DOIs	https://doi.org/10.1016/j.molimm.2013.01.008
Publication status	Published - Jul 2013

Keywords

Adaptor Proteins, Signal Transducing
Apoptosis Regulatory Proteins
C-Reactive Protein
Complement Pathway, Mannose-Binding Lectin
Double-Blind Method
Female
Follow-Up Studies
Glycoproteins
Humans
Lectins
Magnetic Resonance Imaging
Male
Mannose-Binding Lectins
Middle Aged
Myocardial Infarction
Prospective Studies
Randomized Controlled Trials as Topic
Retrospective Studies
Ventricular Remodeling

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10.1016/j.molimm.2013.01.008

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Schoos, M. M., Munthe-Fog, L., Skjoedt, M.-O., Ripa, R. S., Lønborg, J., Kastrup, J., Kelbæk, H., Clemmensen, P., & Garred, P. (2013). Association between lectin complement pathway initiators, C-reactive protein and left ventricular remodeling in myocardial infarction-a magnetic resonance study. Cellular & Molecular Immunology, 54(3-4), 408-14. https://doi.org/10.1016/j.molimm.2013.01.008

Association between lectin complement pathway initiators, C-reactive protein and left ventricular remodeling in myocardial infarction-a magnetic resonance study. / Schoos, Mikkel Malby; Munthe-Fog, Lea; Skjoedt, Mikkel-Ole et al.
In: Cellular & Molecular Immunology, Vol. 54, No. 3-4, 07.2013, p. 408-14.

Research output: Contribution to journal › Journal article › Research › peer-review

Schoos, MM, Munthe-Fog, L, Skjoedt, M-O, Ripa, RS , Lønborg, J , Kastrup, J, Kelbæk, H, Clemmensen, P & Garred, P 2013, 'Association between lectin complement pathway initiators, C-reactive protein and left ventricular remodeling in myocardial infarction-a magnetic resonance study', Cellular & Molecular Immunology, vol. 54, no. 3-4, pp. 408-14. https://doi.org/10.1016/j.molimm.2013.01.008

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title = "Association between lectin complement pathway initiators, C-reactive protein and left ventricular remodeling in myocardial infarction-a magnetic resonance study",

abstract = "Lectin complement pathway (LP) activation is an important mechanism in myocardial ischemia reperfusion injury (IRI). LP is activated via the recognition molecules mannose-binding lectin (MBL), ficolins-2 and-3 and is regulated by MBL/Ficolin-associated Protein-1 (MAP-1). Also, C-reactive protein (CRP) and ficolin-2 interact in vitro, but the role of the ficolins in IRI is unknown.",

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author = "Schoos, \{Mikkel Malby\} and Lea Munthe-Fog and Mikkel-Ole Skjoedt and Ripa, \{Rasmus Sejersten\} and Jacob L{\o}nborg and Jens Kastrup and Henning Kelb{\ae}k and Peter Clemmensen and Peter Garred",

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AU - Schoos, Mikkel Malby

AU - Munthe-Fog, Lea

AU - Skjoedt, Mikkel-Ole

AU - Ripa, Rasmus Sejersten

AU - Lønborg, Jacob

AU - Kastrup, Jens

AU - Kelbæk, Henning

AU - Clemmensen, Peter

AU - Garred, Peter

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AB - Lectin complement pathway (LP) activation is an important mechanism in myocardial ischemia reperfusion injury (IRI). LP is activated via the recognition molecules mannose-binding lectin (MBL), ficolins-2 and-3 and is regulated by MBL/Ficolin-associated Protein-1 (MAP-1). Also, C-reactive protein (CRP) and ficolin-2 interact in vitro, but the role of the ficolins in IRI is unknown.

KW - Adaptor Proteins, Signal Transducing

KW - Apoptosis Regulatory Proteins

KW - C-Reactive Protein

KW - Complement Pathway, Mannose-Binding Lectin

KW - Double-Blind Method

KW - Female

KW - Follow-Up Studies

KW - Glycoproteins

KW - Humans

KW - Lectins

KW - Magnetic Resonance Imaging

KW - Male

KW - Mannose-Binding Lectins

KW - Middle Aged

KW - Myocardial Infarction

KW - Prospective Studies

KW - Randomized Controlled Trials as Topic

KW - Retrospective Studies

KW - Ventricular Remodeling

UR - https://www.scopus.com/pages/publications/84873439074

U2 - 10.1016/j.molimm.2013.01.008

DO - 10.1016/j.molimm.2013.01.008

M3 - Journal article

C2 - 23399387

SN - 1672-7681

VL - 54

SP - 408

EP - 414

JO - Cellular & Molecular Immunology

JF - Cellular & Molecular Immunology

IS - 3-4

ER -

Association between lectin complement pathway initiators, C-reactive protein and left ventricular remodeling in myocardial infarction-a magnetic resonance study

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