Association between interleukin-15 and obesity: interleukin-15 as a potential regulator of fat mass

Anders Rinnov Nielsen; Pernille Hojman; Christian Erikstrup; Christian Philip Fischer; Peter Plomgaard; Remi Mounier; Ole Hartvig Mortensen; Christa Broholm; Sarah Taudorf; Rikke Krogh-Madsen; Birgitte Lindegaard; Anne Marie Winther Petersen; Julie Gehl; Bente Klarlund Pedersen

doi:10.1210/jc.2007-2561

Association between interleukin-15 and obesity: interleukin-15 as a potential regulator of fat mass

Anders Rinnov Nielsen, Pernille Hojman, Christian Erikstrup, Christian Philip Fischer, Peter Plomgaard, Remi Mounier, Ole Hartvig Mortensen, Christa Broholm, Sarah Taudorf, Rikke Krogh-Madsen, Birgitte Lindegaard, Anne Marie Winther Petersen, Julie Gehl, Bente Klarlund Pedersen

Abstract

OBJECTIVE: IL-15 decreases lipid deposition in preadipocytes and decreases the mass of white adipose tissue in rats, indicating that IL-15 may take part in regulating this tissue. IL-15 is expressed in human skeletal muscle and skeletal muscle may be a source of plasma IL-15 and in this way regulate adipose tissue mass.

DESIGN: The relation between skeletal muscle IL-15 mRNA expression, plasma IL-15, and adipose tissue mass was studied in 199 humans divided into four groups on the basis of obesity and type 2 diabetes. Furthermore, using a DNA electrotransfer model, we assessed the effect of IL-15 overexpression in skeletal muscle of mice.

RESULTS: In humans, multiple regression analysis showed a negative association between plasma IL-15 and total fat mass (P<0.05), trunk fat mass (P<0.01), and percent fat mass (P<0.05), independent of type 2 diabetes. Negative associations were also found between muscle IL-15 mRNA and obesity parameters. IL-15 overexpression in skeletal muscle of mice reduced trunk fat mass but not sc fat mass.

CONCLUSIONS: Our results indicate that IL-15 may be a regulator of trunk fat mass.

Original language	English
Journal	The Journal of clinical endocrinology and metabolism
Volume	93
Issue number	11
Pages (from-to)	4486-93
Number of pages	8
ISSN	0021-972X
DOIs	https://doi.org/10.1210/jc.2007-2561
Publication status	Published - Nov 2008
Externally published	Yes

Keywords

Adipocytes/physiology
Adipose Tissue/anatomy & histology
Animals
Body Composition
Body Mass Index
Case-Control Studies
Cross-Sectional Studies
Diabetes Mellitus, Type 2/blood
Female
Glucose Tolerance Test
Homeostasis
Humans
Interleukin-15/blood
Male
Mice
Middle Aged
Muscle, Skeletal/physiology
Obesity/physiopathology
Physical Fitness
RNA, Messenger/genetics
Rats
Reverse Transcriptase Polymerase Chain Reaction

Access to Document

10.1210/jc.2007-2561

Cite this

Nielsen, A. R., Hojman, P., Erikstrup, C., Fischer, C. P., Plomgaard, P., Mounier, R., Mortensen, O. H., Broholm, C., Taudorf, S., Krogh-Madsen, R., Lindegaard, B., Petersen, A. M. W., Gehl, J., & Pedersen, B. K. (2008). Association between interleukin-15 and obesity: interleukin-15 as a potential regulator of fat mass. The Journal of clinical endocrinology and metabolism, 93(11), 4486-93. https://doi.org/10.1210/jc.2007-2561

Nielsen, AR, Hojman, P, Erikstrup, C, Fischer, CP, Plomgaard, P, Mounier, R, Mortensen, OH, Broholm, C, Taudorf, S, Krogh-Madsen, R, Lindegaard, B, Petersen, AMW, Gehl, J & Pedersen, BK 2008, 'Association between interleukin-15 and obesity: interleukin-15 as a potential regulator of fat mass', The Journal of clinical endocrinology and metabolism, vol. 93, no. 11, pp. 4486-93. https://doi.org/10.1210/jc.2007-2561

@article{28222d9d8f7144dabf4d9621427fe493,

title = "Association between interleukin-15 and obesity: interleukin-15 as a potential regulator of fat mass",

abstract = "OBJECTIVE: IL-15 decreases lipid deposition in preadipocytes and decreases the mass of white adipose tissue in rats, indicating that IL-15 may take part in regulating this tissue. IL-15 is expressed in human skeletal muscle and skeletal muscle may be a source of plasma IL-15 and in this way regulate adipose tissue mass.DESIGN: The relation between skeletal muscle IL-15 mRNA expression, plasma IL-15, and adipose tissue mass was studied in 199 humans divided into four groups on the basis of obesity and type 2 diabetes. Furthermore, using a DNA electrotransfer model, we assessed the effect of IL-15 overexpression in skeletal muscle of mice.RESULTS: In humans, multiple regression analysis showed a negative association between plasma IL-15 and total fat mass (P<0.05), trunk fat mass (P<0.01), and percent fat mass (P<0.05), independent of type 2 diabetes. Negative associations were also found between muscle IL-15 mRNA and obesity parameters. IL-15 overexpression in skeletal muscle of mice reduced trunk fat mass but not sc fat mass.CONCLUSIONS: Our results indicate that IL-15 may be a regulator of trunk fat mass.",

keywords = "Adipocytes/physiology, Adipose Tissue/anatomy & histology, Animals, Body Composition, Body Mass Index, Case-Control Studies, Cross-Sectional Studies, Diabetes Mellitus, Type 2/blood, Female, Glucose Tolerance Test, Homeostasis, Humans, Interleukin-15/blood, Male, Mice, Middle Aged, Muscle, Skeletal/physiology, Obesity/physiopathology, Physical Fitness, RNA, Messenger/genetics, Rats, Reverse Transcriptase Polymerase Chain Reaction",

author = "Nielsen, {Anders Rinnov} and Pernille Hojman and Christian Erikstrup and Fischer, {Christian Philip} and Peter Plomgaard and Remi Mounier and Mortensen, {Ole Hartvig} and Christa Broholm and Sarah Taudorf and Rikke Krogh-Madsen and Birgitte Lindegaard and Petersen, {Anne Marie Winther} and Julie Gehl and Pedersen, {Bente Klarlund}",

year = "2008",

month = nov,

doi = "10.1210/jc.2007-2561",

language = "English",

volume = "93",

pages = "4486--93",

journal = "The Journal of clinical endocrinology and metabolism",

issn = "0021-972X",

publisher = "The/Endocrine Society",

number = "11",

}

TY - JOUR

T1 - Association between interleukin-15 and obesity

T2 - interleukin-15 as a potential regulator of fat mass

AU - Nielsen, Anders Rinnov

AU - Hojman, Pernille

AU - Erikstrup, Christian

AU - Fischer, Christian Philip

AU - Plomgaard, Peter

AU - Mounier, Remi

AU - Mortensen, Ole Hartvig

AU - Broholm, Christa

AU - Taudorf, Sarah

AU - Krogh-Madsen, Rikke

AU - Lindegaard, Birgitte

AU - Petersen, Anne Marie Winther

AU - Gehl, Julie

AU - Pedersen, Bente Klarlund

PY - 2008/11

Y1 - 2008/11

N2 - OBJECTIVE: IL-15 decreases lipid deposition in preadipocytes and decreases the mass of white adipose tissue in rats, indicating that IL-15 may take part in regulating this tissue. IL-15 is expressed in human skeletal muscle and skeletal muscle may be a source of plasma IL-15 and in this way regulate adipose tissue mass.DESIGN: The relation between skeletal muscle IL-15 mRNA expression, plasma IL-15, and adipose tissue mass was studied in 199 humans divided into four groups on the basis of obesity and type 2 diabetes. Furthermore, using a DNA electrotransfer model, we assessed the effect of IL-15 overexpression in skeletal muscle of mice.RESULTS: In humans, multiple regression analysis showed a negative association between plasma IL-15 and total fat mass (P<0.05), trunk fat mass (P<0.01), and percent fat mass (P<0.05), independent of type 2 diabetes. Negative associations were also found between muscle IL-15 mRNA and obesity parameters. IL-15 overexpression in skeletal muscle of mice reduced trunk fat mass but not sc fat mass.CONCLUSIONS: Our results indicate that IL-15 may be a regulator of trunk fat mass.

AB - OBJECTIVE: IL-15 decreases lipid deposition in preadipocytes and decreases the mass of white adipose tissue in rats, indicating that IL-15 may take part in regulating this tissue. IL-15 is expressed in human skeletal muscle and skeletal muscle may be a source of plasma IL-15 and in this way regulate adipose tissue mass.DESIGN: The relation between skeletal muscle IL-15 mRNA expression, plasma IL-15, and adipose tissue mass was studied in 199 humans divided into four groups on the basis of obesity and type 2 diabetes. Furthermore, using a DNA electrotransfer model, we assessed the effect of IL-15 overexpression in skeletal muscle of mice.RESULTS: In humans, multiple regression analysis showed a negative association between plasma IL-15 and total fat mass (P<0.05), trunk fat mass (P<0.01), and percent fat mass (P<0.05), independent of type 2 diabetes. Negative associations were also found between muscle IL-15 mRNA and obesity parameters. IL-15 overexpression in skeletal muscle of mice reduced trunk fat mass but not sc fat mass.CONCLUSIONS: Our results indicate that IL-15 may be a regulator of trunk fat mass.

KW - Adipocytes/physiology

KW - Adipose Tissue/anatomy & histology

KW - Animals

KW - Body Composition

KW - Body Mass Index

KW - Case-Control Studies

KW - Cross-Sectional Studies

KW - Diabetes Mellitus, Type 2/blood

KW - Female

KW - Glucose Tolerance Test

KW - Homeostasis

KW - Humans

KW - Interleukin-15/blood

KW - Male

KW - Mice

KW - Middle Aged

KW - Muscle, Skeletal/physiology

KW - Obesity/physiopathology

KW - Physical Fitness

KW - RNA, Messenger/genetics

KW - Rats

KW - Reverse Transcriptase Polymerase Chain Reaction

U2 - 10.1210/jc.2007-2561

DO - 10.1210/jc.2007-2561

M3 - Journal article

C2 - 18697873

SN - 0021-972X

VL - 93

SP - 4486

EP - 4493

JO - The Journal of clinical endocrinology and metabolism

JF - The Journal of clinical endocrinology and metabolism

IS - 11

ER -

Association between interleukin-15 and obesity: interleukin-15 as a potential regulator of fat mass

Abstract

Keywords

Access to Document

Fingerprint

Cite this