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Association between GLP-1 receptor gene polymorphisms with reward learning, anhedonia and depression diagnosis

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Yapici-Eser, H, Appadurai, V, Eren, CY, Yazici, D, Chen, C-Y, Öngür, D, Pizzagalli, DA, Werge, T & Hall, M-H 2020, 'Association between GLP-1 receptor gene polymorphisms with reward learning, anhedonia and depression diagnosis', Acta Neuropsychiatrica, vol. 32, no. 4, pp. 218-225. https://doi.org/10.1017/neu.2020.14

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Yapici-Eser, Hale ; Appadurai, Vivek ; Eren, Candan Yasemin ; Yazici, Dilek ; Chen, Chia-Yen ; Öngür, Dost ; Pizzagalli, Diego A ; Werge, Thomas ; Hall, Mei-Hua. / Association between GLP-1 receptor gene polymorphisms with reward learning, anhedonia and depression diagnosis. In: Acta Neuropsychiatrica. 2020 ; Vol. 32, No. 4. pp. 218-225.

Bibtex

@article{663ac4982cd941c491b222524993ffe0,
title = "Association between GLP-1 receptor gene polymorphisms with reward learning, anhedonia and depression diagnosis",
abstract = "BACKGROUND: Glucagon-like peptide-1 receptors (GLP-1Rs) are widely expressed in the brain. Evidence suggests that they may play a role in reward responses and neuroprotection. However, the association of GLP-1R with anhedonia and depression diagnosis has not been studied. Here, we examined the association of GLP-1R polymorphisms with objective and subjective measures of anhedonia, as well as depression diagnosis.METHODS: Objective [response bias assessed by the probabilistic reward task (PRT)] and subjective [Snaith-Hamilton Pleasure Scale (SHAPS)] measures of anhedonia, clinical variables and DNA samples were collected from 100 controls and 164 patients at McLean Hospital. An independent sample genotyped as part of the Psychiatric Genomics Consortium (PGC) was used to study the effect of putative GLP-1R polymorphisms linked to response bias in PRT on depression diagnosis.RESULTS: The C allele in rs1042044 was significantly associated with increased PRT response bias, when controlling for age, sex, case-control status and PRT discriminability. AA genotype of rs1042044 showed higher anhedonia phenotype based on SHAPS scores. However, analysis of PGC major depressive disorder data showed no association between rs1042044 and depression diagnosis.CONCLUSION: Findings suggest a possible association of rs1042044 with anhedonia but no association with depression diagnosis.",
keywords = "Anhedonia/physiology, Case-Control Studies, Correlation of Data, Depressive Disorder/diagnosis, Depressive Disorder, Major/diagnosis, Genotype, Glucagon-Like Peptide-1 Receptor/genetics, Humans, Learning/physiology, Phenotype, Polymorphism, Genetic/genetics, Reward",
author = "Hale Yapici-Eser and Vivek Appadurai and Eren, {Candan Yasemin} and Dilek Yazici and Chia-Yen Chen and Dost {\"O}ng{\"u}r and Pizzagalli, {Diego A} and Thomas Werge and Mei-Hua Hall",
year = "2020",
month = aug,
doi = "10.1017/neu.2020.14",
language = "English",
volume = "32",
pages = "218--225",
journal = "Acta Neuropsychiatrica (Online)",
issn = "1601-5215",
publisher = "Wiley-Blackwell Publishing, Inc",
number = "4",

}

RIS

TY - JOUR

T1 - Association between GLP-1 receptor gene polymorphisms with reward learning, anhedonia and depression diagnosis

AU - Yapici-Eser, Hale

AU - Appadurai, Vivek

AU - Eren, Candan Yasemin

AU - Yazici, Dilek

AU - Chen, Chia-Yen

AU - Öngür, Dost

AU - Pizzagalli, Diego A

AU - Werge, Thomas

AU - Hall, Mei-Hua

PY - 2020/8

Y1 - 2020/8

N2 - BACKGROUND: Glucagon-like peptide-1 receptors (GLP-1Rs) are widely expressed in the brain. Evidence suggests that they may play a role in reward responses and neuroprotection. However, the association of GLP-1R with anhedonia and depression diagnosis has not been studied. Here, we examined the association of GLP-1R polymorphisms with objective and subjective measures of anhedonia, as well as depression diagnosis.METHODS: Objective [response bias assessed by the probabilistic reward task (PRT)] and subjective [Snaith-Hamilton Pleasure Scale (SHAPS)] measures of anhedonia, clinical variables and DNA samples were collected from 100 controls and 164 patients at McLean Hospital. An independent sample genotyped as part of the Psychiatric Genomics Consortium (PGC) was used to study the effect of putative GLP-1R polymorphisms linked to response bias in PRT on depression diagnosis.RESULTS: The C allele in rs1042044 was significantly associated with increased PRT response bias, when controlling for age, sex, case-control status and PRT discriminability. AA genotype of rs1042044 showed higher anhedonia phenotype based on SHAPS scores. However, analysis of PGC major depressive disorder data showed no association between rs1042044 and depression diagnosis.CONCLUSION: Findings suggest a possible association of rs1042044 with anhedonia but no association with depression diagnosis.

AB - BACKGROUND: Glucagon-like peptide-1 receptors (GLP-1Rs) are widely expressed in the brain. Evidence suggests that they may play a role in reward responses and neuroprotection. However, the association of GLP-1R with anhedonia and depression diagnosis has not been studied. Here, we examined the association of GLP-1R polymorphisms with objective and subjective measures of anhedonia, as well as depression diagnosis.METHODS: Objective [response bias assessed by the probabilistic reward task (PRT)] and subjective [Snaith-Hamilton Pleasure Scale (SHAPS)] measures of anhedonia, clinical variables and DNA samples were collected from 100 controls and 164 patients at McLean Hospital. An independent sample genotyped as part of the Psychiatric Genomics Consortium (PGC) was used to study the effect of putative GLP-1R polymorphisms linked to response bias in PRT on depression diagnosis.RESULTS: The C allele in rs1042044 was significantly associated with increased PRT response bias, when controlling for age, sex, case-control status and PRT discriminability. AA genotype of rs1042044 showed higher anhedonia phenotype based on SHAPS scores. However, analysis of PGC major depressive disorder data showed no association between rs1042044 and depression diagnosis.CONCLUSION: Findings suggest a possible association of rs1042044 with anhedonia but no association with depression diagnosis.

KW - Anhedonia/physiology

KW - Case-Control Studies

KW - Correlation of Data

KW - Depressive Disorder/diagnosis

KW - Depressive Disorder, Major/diagnosis

KW - Genotype

KW - Glucagon-Like Peptide-1 Receptor/genetics

KW - Humans

KW - Learning/physiology

KW - Phenotype

KW - Polymorphism, Genetic/genetics

KW - Reward

U2 - 10.1017/neu.2020.14

DO - 10.1017/neu.2020.14

M3 - Journal article

C2 - 32213216

VL - 32

SP - 218

EP - 225

JO - Acta Neuropsychiatrica (Online)

JF - Acta Neuropsychiatrica (Online)

SN - 1601-5215

IS - 4

ER -

ID: 67994963