Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Association between GLP-1 receptor gene polymorphisms with reward learning, anhedonia and depression diagnosis

Research output: Contribution to journalJournal articlepeer-review

DOI

  1. Mental well-being, health, and locus of control in Danish adults before and during COVID-19

    Research output: Contribution to journalJournal articlepeer-review

  2. Light therapy for seasonal affective disorder in visual impairment and blindness - a pilot study

    Research output: Contribution to journalJournal articlepeer-review

  3. Differentiating Depression and ADHD without Depression in Adults with Processing-Speed Measures

    Research output: Contribution to journalJournal articlepeer-review

  4. Low frequency rTMS, inhibits the antidepressive effect of ECT. A pilot study

    Research output: Contribution to journalJournal articlepeer-review

  5. Markers of HPA-axis activity and nucleic acid damage from oxidation after electroconvulsive stimulations in rats

    Research output: Contribution to journalJournal articlepeer-review

  1. Maternal pregnancy-related infections and autism spectrum disorder-the genetic perspective

    Research output: Contribution to journalJournal articlepeer-review

  2. Deep learning-based integration of genetics with registry data for stratification of schizophrenia and depression

    Research output: Contribution to journalJournal articlepeer-review

  3. Cohort Profile: COVIDMENT: COVID-19 cohorts on mental health across six nations

    Research output: Contribution to journalJournal articlepeer-review

View graph of relations

BACKGROUND: Glucagon-like peptide-1 receptors (GLP-1Rs) are widely expressed in the brain. Evidence suggests that they may play a role in reward responses and neuroprotection. However, the association of GLP-1R with anhedonia and depression diagnosis has not been studied. Here, we examined the association of GLP-1R polymorphisms with objective and subjective measures of anhedonia, as well as depression diagnosis.

METHODS: Objective [response bias assessed by the probabilistic reward task (PRT)] and subjective [Snaith-Hamilton Pleasure Scale (SHAPS)] measures of anhedonia, clinical variables and DNA samples were collected from 100 controls and 164 patients at McLean Hospital. An independent sample genotyped as part of the Psychiatric Genomics Consortium (PGC) was used to study the effect of putative GLP-1R polymorphisms linked to response bias in PRT on depression diagnosis.

RESULTS: The C allele in rs1042044 was significantly associated with increased PRT response bias, when controlling for age, sex, case-control status and PRT discriminability. AA genotype of rs1042044 showed higher anhedonia phenotype based on SHAPS scores. However, analysis of PGC major depressive disorder data showed no association between rs1042044 and depression diagnosis.

CONCLUSION: Findings suggest a possible association of rs1042044 with anhedonia but no association with depression diagnosis.

Original languageEnglish
JournalActa Neuropsychiatrica
Volume32
Issue number4
Pages (from-to)218-225
Number of pages8
ISSN1601-5215
DOIs
Publication statusPublished - Aug 2020

    Research areas

  • Anhedonia/physiology, Case-Control Studies, Correlation of Data, Depressive Disorder/diagnosis, Depressive Disorder, Major/diagnosis, Genotype, Glucagon-Like Peptide-1 Receptor/genetics, Humans, Learning/physiology, Phenotype, Polymorphism, Genetic/genetics, Reward

ID: 67994963