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Association between genes on chromosome 19p13.2 and panic disorder

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Harvard

Gregersen, NO, Buttenschøn, HN, Hedemand, A, Nielsen, MN, Dahl, HA, Kristensen, AS, Johansen, O, Woldbye, DPD, Erhardt, A, Kruse, TA, Wang, AG, Børglum, AD & Mors, O 2016, 'Association between genes on chromosome 19p13.2 and panic disorder' Psychiatric Genetics, vol. 26, no. 6, pp. 287-292. https://doi.org/10.1097/YPG.0000000000000147

APA

Gregersen, N. O., Buttenschøn, H. N., Hedemand, A., Nielsen, M. N., Dahl, H. A., Kristensen, A. S., ... Mors, O. (2016). Association between genes on chromosome 19p13.2 and panic disorder. Psychiatric Genetics, 26(6), 287-292. https://doi.org/10.1097/YPG.0000000000000147

CBE

Gregersen NO, Buttenschøn HN, Hedemand A, Nielsen MN, Dahl HA, Kristensen AS, Johansen O, Woldbye DPD, Erhardt A, Kruse TA, Wang AG, Børglum AD, Mors O. 2016. Association between genes on chromosome 19p13.2 and panic disorder. Psychiatric Genetics. 26(6):287-292. https://doi.org/10.1097/YPG.0000000000000147

MLA

Vancouver

Gregersen NO, Buttenschøn HN, Hedemand A, Nielsen MN, Dahl HA, Kristensen AS et al. Association between genes on chromosome 19p13.2 and panic disorder. Psychiatric Genetics. 2016 Dec;26(6):287-292. https://doi.org/10.1097/YPG.0000000000000147

Author

Gregersen, Noomi O ; Buttenschøn, Henriette N ; Hedemand, Anne ; Nielsen, Marit N ; Dahl, Hans A ; Kristensen, Ann S ; Johansen, Oddbjørg ; Woldbye, David P D ; Erhardt, Angelika ; Kruse, Torben A ; Wang, August G ; Børglum, Anders D ; Mors, Ole. / Association between genes on chromosome 19p13.2 and panic disorder. In: Psychiatric Genetics. 2016 ; Vol. 26, No. 6. pp. 287-292.

Bibtex

@article{12f77ec4fdfc432da7b0f905999d6dbd,
title = "Association between genes on chromosome 19p13.2 and panic disorder",
abstract = "Panic disorder (PD) is a severe and disabling mental disorder, which is moderately heritable. In a previous study, we carried out a genome-wide association study using patients with PD and control individuals from the isolated population of the Faroe Islands and identified chromosome 19p13.2 as a candidate region. To further investigate this chromosomal region for association with PD, we analysed eight single nucleotide polymorphisms (SNPs) in three candidate genes - small-nuclear RNA activating complex, polypeptide 2 (SNAPC2), mitogen-activated protein kinase kinase 7 (MAP2K7) and leucine-rich repeat containing 8 family, member E (LRRC8E) - these genes have previously been directly or indirectly implicated in other mental disorders. A total of 511 patients with PD and 1029 healthy control individuals from the Faroe Islands, Denmark and Germany were included in the current study. SNPs covering the gene region of SNAPC2, MAP2K7 and LRRC8E were genotyped and tested for association with PD. In the Faroese cohort, rs7788 within SNAPC2 was significantly associated with PD, whereas rs3745383 within LRRC8E was nominally associated. No association was observed between the analysed SNPs and PD in the Danish cohorts. In the German women, we observed a nominal association between rs4804833 within MAP2K7 and PD. We present further evidence that chromosome 19p13.2 may harbour candidate genes that contribute towards the risk of developing PD. Moreover, the implication of the associated genes in other mental disorders may indicate shared genetic susceptibility between mental disorders. We show that associated variants may be sex specific, indicating the importance of carrying out a sex-specific association analysis of PD.",
author = "Gregersen, {Noomi O} and Buttensch{\o}n, {Henriette N} and Anne Hedemand and Nielsen, {Marit N} and Dahl, {Hans A} and Kristensen, {Ann S} and Oddbj{\o}rg Johansen and Woldbye, {David P D} and Angelika Erhardt and Kruse, {Torben A} and Wang, {August G} and B{\o}rglum, {Anders D} and Ole Mors",
year = "2016",
month = "12",
doi = "10.1097/YPG.0000000000000147",
language = "English",
volume = "26",
pages = "287--292",
journal = "Psychiatric Genetics",
issn = "0955-8829",
publisher = "Lippincott Williams & Wilkins",
number = "6",

}

RIS

TY - JOUR

T1 - Association between genes on chromosome 19p13.2 and panic disorder

AU - Gregersen, Noomi O

AU - Buttenschøn, Henriette N

AU - Hedemand, Anne

AU - Nielsen, Marit N

AU - Dahl, Hans A

AU - Kristensen, Ann S

AU - Johansen, Oddbjørg

AU - Woldbye, David P D

AU - Erhardt, Angelika

AU - Kruse, Torben A

AU - Wang, August G

AU - Børglum, Anders D

AU - Mors, Ole

PY - 2016/12

Y1 - 2016/12

N2 - Panic disorder (PD) is a severe and disabling mental disorder, which is moderately heritable. In a previous study, we carried out a genome-wide association study using patients with PD and control individuals from the isolated population of the Faroe Islands and identified chromosome 19p13.2 as a candidate region. To further investigate this chromosomal region for association with PD, we analysed eight single nucleotide polymorphisms (SNPs) in three candidate genes - small-nuclear RNA activating complex, polypeptide 2 (SNAPC2), mitogen-activated protein kinase kinase 7 (MAP2K7) and leucine-rich repeat containing 8 family, member E (LRRC8E) - these genes have previously been directly or indirectly implicated in other mental disorders. A total of 511 patients with PD and 1029 healthy control individuals from the Faroe Islands, Denmark and Germany were included in the current study. SNPs covering the gene region of SNAPC2, MAP2K7 and LRRC8E were genotyped and tested for association with PD. In the Faroese cohort, rs7788 within SNAPC2 was significantly associated with PD, whereas rs3745383 within LRRC8E was nominally associated. No association was observed between the analysed SNPs and PD in the Danish cohorts. In the German women, we observed a nominal association between rs4804833 within MAP2K7 and PD. We present further evidence that chromosome 19p13.2 may harbour candidate genes that contribute towards the risk of developing PD. Moreover, the implication of the associated genes in other mental disorders may indicate shared genetic susceptibility between mental disorders. We show that associated variants may be sex specific, indicating the importance of carrying out a sex-specific association analysis of PD.

AB - Panic disorder (PD) is a severe and disabling mental disorder, which is moderately heritable. In a previous study, we carried out a genome-wide association study using patients with PD and control individuals from the isolated population of the Faroe Islands and identified chromosome 19p13.2 as a candidate region. To further investigate this chromosomal region for association with PD, we analysed eight single nucleotide polymorphisms (SNPs) in three candidate genes - small-nuclear RNA activating complex, polypeptide 2 (SNAPC2), mitogen-activated protein kinase kinase 7 (MAP2K7) and leucine-rich repeat containing 8 family, member E (LRRC8E) - these genes have previously been directly or indirectly implicated in other mental disorders. A total of 511 patients with PD and 1029 healthy control individuals from the Faroe Islands, Denmark and Germany were included in the current study. SNPs covering the gene region of SNAPC2, MAP2K7 and LRRC8E were genotyped and tested for association with PD. In the Faroese cohort, rs7788 within SNAPC2 was significantly associated with PD, whereas rs3745383 within LRRC8E was nominally associated. No association was observed between the analysed SNPs and PD in the Danish cohorts. In the German women, we observed a nominal association between rs4804833 within MAP2K7 and PD. We present further evidence that chromosome 19p13.2 may harbour candidate genes that contribute towards the risk of developing PD. Moreover, the implication of the associated genes in other mental disorders may indicate shared genetic susceptibility between mental disorders. We show that associated variants may be sex specific, indicating the importance of carrying out a sex-specific association analysis of PD.

U2 - 10.1097/YPG.0000000000000147

DO - 10.1097/YPG.0000000000000147

M3 - Journal article

VL - 26

SP - 287

EP - 292

JO - Psychiatric Genetics

JF - Psychiatric Genetics

SN - 0955-8829

IS - 6

ER -

ID: 49262218