Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
E-pub ahead of print

Association between childhood asthma and attention deficit hyperactivity or autism spectrum disorders: A systematic review with meta-analysis

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Parent-specific effects on risk of developing allergic sensitization and asthma in childhood

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Identifying and managing patients at risk of severe allergic reactions to food: Report from two iFAAM workshops

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Retrospective markers of paediatric atopic dermatitis persistence after hospital diagnosis: A nationwide cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. FUT2-ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Prenatal dietary supplements influence the infant airway microbiota in a randomized factorial clinical trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Epigenetic landscape links upper airway microbiota in infancy with allergic rhinitis at 6 years of age

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Children with asthma are at risk of depression and anxiety and growing evidence suggest they may also be at risk of attention deficit hyperreactivity disorder (ADHD) and autism spectrum disorder (ASD). Here, we conducted a systematic review with meta-analysis of studies investigating association between asthma and ADHD or ASD in children.

METHODS: A comprehensive search using PubMed, EMBASE and Cochrane Library databases was completed in March 2019. Observational human studies published in English, clinic-based or population-based with a healthy comparator group, evaluating asthma-ADHD or asthma-ASD overlap in children 18 years or younger using categorical diagnoses (yes/no) were considered for inclusion. Random effects meta-analysis models were used to analyse data. The Newcastle Ottawa Scale was used to evaluate risk of bias.

RESULTS: A total of 25 asthma-ADHD studies were included of which 17 showed significant positive associations and one a negative association: 17/25 studies were population-based, 19/25 were cross-sectional or cohort studies and 7/25 had a low risk of bias. We performed a meta-analysis of 23 of the studies, which showed a significant association between asthma and ADHD: odds ratio (OR) 1.52 (1.42-1.63), P < .001, I2 = 60%. All studies were adjusted for age and sex and a large proportion; that is, 19/23 were further adjusted for relevant confounders. Seventeen asthma-ASD studies were included, whereof 7 showed a positive association and 3 a negative association; 8/17 were population-based with a cross-sectional study design and 4/17 had a low risk of bias. We performed a meta-analysis of 14 of the studies, which did not show a significant association between asthma and ASD: OR 1.12 (0.93-1.34), P = .24, I2 = 89%. All studies were adjusted for age and sex and 10/14 were further adjusted for relevant confounders.

CONCLUSIONS: This systematic review with meta-analyses shows a significant overlap between asthma and ADHD, but not between asthma and ASD in children. Clinicians taking care of children with asthma or ADHD should be aware of such association to aid an early diagnosis and treatment of such comorbidity.

Original languageEnglish
JournalClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
ISSN0954-7894
DOIs
Publication statusE-pub ahead of print - 30 Sep 2020

Bibliographical note

© 2020 John Wiley & Sons Ltd.

ID: 61273219