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Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes

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Aims:  The relation of disease progression and age, serum interleukin 10 (IL-10) and interferon gamma (IFNγ) and their genetic correlates were studied in paediatric patients with newly diagnosed Type 1 diabetes. Methods:  Two hundred and twenty-seven patients from the Hvidoere Study Group were classified in four different progression groups as assessed by change in stimulated C-peptide from 1 to 6 months. CA repeat variants of the IL-10 and IFNγ gene were genotyped and serum levels of IL-10 and IFNγ were measured at 1, 6 and 12 months. Results:  IL-10 decreased (P 
Original languageEnglish
JournalDiabetic Medicine
Volume29
Issue number6
Pages (from-to)734-741
Number of pages8
ISSN0742-3071
DOIs
Publication statusPublished - 2012

ID: 34783259