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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Association between 3-Iodothyronamine (T1AM) Concentrations and Left Ventricular Function in Chronic Heart Failure

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Objective: To investigate concentration of T1AM and its association with LVEF and biomarkers of heart function in chronic heart failure (CHF) patients without thyroid disease, including patients with cardiac cachexia (non-oedematous weight loss >5% over 6 months).

Methods: Cross sectional study. CHF was characterized by LVEF <45 % and symptoms. Three groups were included (n=19 in each group, matched on age, sex, and kidney function): patients with cachexia (CAC), or without (NON-CAC), and controls with prior myocardial infarction and LVEF >45 % (C). T1AM were measured by a monoclonal antibody-based chemiluminescence immunoassay. NT-proBNP concentrations were also analysed.

Results: Mean (SD) LVEF: CAC: 32% ±9; NON-CAC: 38% ±8 and C: 60% ±8, (p < 0.0001). TSH, T4, T3 did not differ between groups, and did not correlate to T1AM. Serum T1AM (nmol/l) concentrations were higher in CHF: CAC: (mean ± SD) 12.4 ± 6.6, NON-CAC: 9.1 ± 5 and C: 7.3 ± 2.9. A negative association between T1AM and LVEF was present after adjusting for sex, age, T3 and estimated GFR (p=0.03). Further, serum T1AM levels tended to be associated with NT-proBNP (p= 0.053).

Conclusion: Serum T1AM levels were increased in patients with CHF, and numerically highest (although non-significant) in patients with cardiac cachexia. Increasing T1AM concentrations were independently associated with reduced LVEF suggesting a direct effect on the human heart.

Original languageEnglish
JournalThe Journal of clinical endocrinology and metabolism
ISSN0021-972X
DOIs
Publication statusPublished - 31 Oct 2018

ID: 56643965