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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Association analyses identify 31 new risk loci for colorectal cancer susceptibility

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  1. Whole genome landscapes of uveal melanoma show an ultraviolet radiation signature in iris tumours

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  2. Author Correction: Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma

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  3. Genomic analysis of male puberty timing highlights shared genetic basis with hair colour and lifespan

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  4. Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin

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  5. Combined burden and functional impact tests for cancer driver discovery using DriverPower

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  1. Genetic variation at PPP1R3B increases hepatic CT attenuation and interacts with prandial status on plasma glucose

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  2. Tocilizumab and soluble interleukin-6 receptor in JAK2V617F somatic mutation and myeloproliferative neoplasm

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  3. Impact of Glucose Level on Micro- and Macrovascular Disease in the General Population: A Mendelian Randomization Study

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  4. Two-fold risk of pneumonia and respiratory mortality in individuals with myeloproliferative neoplasm: A population-based cohort study

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Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases and 71,379 controls of European ancestry that identifies SNPs at 31 new CRC risk loci. We also identify eight independent risk SNPs at the new and previously reported European CRC loci, and a further nine CRC SNPs at loci previously only identified in Asian populations. We use in situ promoter capture Hi-C (CHi-C), gene expression, and in silico annotation methods to identify likely target genes of CRC SNPs. Whilst these new SNP associations implicate target genes that are enriched for known CRC pathways such as Wnt and BMP, they also highlight novel pathways with no prior links to colorectal tumourigenesis. These findings provide further insight into CRC susceptibility and enhance the prospects of applying genetic risk scores to personalised screening and prevention.

Original languageEnglish
JournalNature Communications
Volume10
Issue number1
Pages (from-to)2154
ISSN2041-1723
DOIs
Publication statusPublished - 14 May 2019

    Research areas

  • Asian Continental Ancestry Group/genetics, Case-Control Studies, Colorectal Neoplasms/genetics, Datasets as Topic, European Continental Ancestry Group/genetics, Female, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Inheritance Patterns, Male, Middle Aged, Polymorphism, Single Nucleotide, Risk Factors

ID: 59309387