Assignment of the human gene for pregnancy-associated plasma protein A (PAPPA) to 9q33.1 by fluorescence in situ hybridization to mitotic and meiotic chromosomes

A N Silahtaroglu; Z Tümer; T Kristensen; L Sottrup-Jensen; N Tommerup

doi:10.1159/000133479

Assignment of the human gene for pregnancy-associated plasma protein A (PAPPA) to 9q33.1 by fluorescence in situ hybridization to mitotic and meiotic chromosomes

A N Silahtaroglu, Z Tümer, T Kristensen, L Sottrup-Jensen, N Tommerup

36 Citations (Scopus)

Abstract

Low levels of pregnancy-associated plasma protein A (PAPPA) during the first trimester has been suggested as a biochemical indicator of pregnancies with aneuploid fetuses. Furthermore, the complete absence of PAPPA in pregnancies associated with Cornelia de Lange syndrome (CL) has suggested a causal connection between PAPPA and the development of CL. We have assigned the locus for PAPPA to chromosome region 9q33.1 on mitotic and meiotic chromosomes by fluorescence in situ hybridization, using a 3.7-kb partial PAPPA cDNA probe.

Original language	English
Journal	Cytogenetics and Cell Genetics
Volume	62
Issue number	4
Pages (from-to)	214-6
Number of pages	3
ISSN	0301-0171
DOIs	https://doi.org/10.1159/000133479
Publication status	Published - 1993
Externally published	Yes

Keywords

Chromosome Mapping
Chromosomes, Human, Pair 9
DNA Probes
Female
Humans
In Situ Hybridization, Fluorescence
Male
Meiosis
Mitosis
Molecular Sequence Data
Pregnancy-Associated Plasma Protein-A/genetics

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10.1159/000133479

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Assignment of the human gene for pregnancy-associated plasma protein A (PAPPA) to 9q33.1 by fluorescence in situ hybridization to mitotic and meiotic chromosomes. / Silahtaroglu, A N; Tümer, Z; Kristensen, T et al.
In: Cytogenetics and Cell Genetics, Vol. 62, No. 4, 1993, p. 214-6.

Research output: Contribution to journal › Journal article › Research › peer-review

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abstract = "Low levels of pregnancy-associated plasma protein A (PAPPA) during the first trimester has been suggested as a biochemical indicator of pregnancies with aneuploid fetuses. Furthermore, the complete absence of PAPPA in pregnancies associated with Cornelia de Lange syndrome (CL) has suggested a causal connection between PAPPA and the development of CL. We have assigned the locus for PAPPA to chromosome region 9q33.1 on mitotic and meiotic chromosomes by fluorescence in situ hybridization, using a 3.7-kb partial PAPPA cDNA probe.",

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AU - Tümer, Z

AU - Kristensen, T

AU - Sottrup-Jensen, L

AU - Tommerup, N

PY - 1993

Y1 - 1993

N2 - Low levels of pregnancy-associated plasma protein A (PAPPA) during the first trimester has been suggested as a biochemical indicator of pregnancies with aneuploid fetuses. Furthermore, the complete absence of PAPPA in pregnancies associated with Cornelia de Lange syndrome (CL) has suggested a causal connection between PAPPA and the development of CL. We have assigned the locus for PAPPA to chromosome region 9q33.1 on mitotic and meiotic chromosomes by fluorescence in situ hybridization, using a 3.7-kb partial PAPPA cDNA probe.

AB - Low levels of pregnancy-associated plasma protein A (PAPPA) during the first trimester has been suggested as a biochemical indicator of pregnancies with aneuploid fetuses. Furthermore, the complete absence of PAPPA in pregnancies associated with Cornelia de Lange syndrome (CL) has suggested a causal connection between PAPPA and the development of CL. We have assigned the locus for PAPPA to chromosome region 9q33.1 on mitotic and meiotic chromosomes by fluorescence in situ hybridization, using a 3.7-kb partial PAPPA cDNA probe.

KW - Chromosome Mapping

KW - Chromosomes, Human, Pair 9

KW - DNA Probes

KW - Female

KW - Humans

KW - In Situ Hybridization, Fluorescence

KW - Male

KW - Meiosis

KW - Mitosis

KW - Molecular Sequence Data

KW - Pregnancy-Associated Plasma Protein-A/genetics

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VL - 62

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EP - 216

JO - Cytogenetics and Cell Genetics

JF - Cytogenetics and Cell Genetics

IS - 4

ER -

Assignment of the human gene for pregnancy-associated plasma protein A (PAPPA) to 9q33.1 by fluorescence in situ hybridization to mitotic and meiotic chromosomes

Abstract

Keywords

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