Assignment of the human gene for pregnancy-associated plasma protein A (PAPPA) to 9q33.1 by fluorescence in situ hybridization to mitotic and meiotic chromosomes

A N Silahtaroglu, Z Tümer, T Kristensen, L Sottrup-Jensen, N Tommerup

Abstract

Low levels of pregnancy-associated plasma protein A (PAPPA) during the first trimester has been suggested as a biochemical indicator of pregnancies with aneuploid fetuses. Furthermore, the complete absence of PAPPA in pregnancies associated with Cornelia de Lange syndrome (CL) has suggested a causal connection between PAPPA and the development of CL. We have assigned the locus for PAPPA to chromosome region 9q33.1 on mitotic and meiotic chromosomes by fluorescence in situ hybridization, using a 3.7-kb partial PAPPA cDNA probe.

Original languageEnglish
JournalCytogenetics and Cell Genetics
Volume62
Issue number4
Pages (from-to)214-6
Number of pages3
ISSN0301-0171
DOIs
Publication statusPublished - 1993
Externally publishedYes

Keywords

  • Chromosome Mapping
  • Chromosomes, Human, Pair 9
  • DNA Probes
  • Female
  • Humans
  • In Situ Hybridization, Fluorescence
  • Male
  • Meiosis
  • Mitosis
  • Molecular Sequence Data
  • Pregnancy-Associated Plasma Protein-A/genetics

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