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Assessment of lung microstructure with magnetic resonance imaging of hyperpolarized Helium-3.

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Schreiber WG, Morbach AE, Stavngaard T, Gast KK, Herweling A, Søgaard L, Windirsch M, Scmiedeskamp J, Heussel CP, Kauczor H-U. 2005. Assessment of lung microstructure with magnetic resonance imaging of hyperpolarized Helium-3. Respir Physiol Neurobiol. 148(1-2):23-42.

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Schreiber, Wolfgang G. ; Morbach, Andreas E ; Stavngaard, Trine ; Gast, Klaus K. ; Herweling, Anette ; Søgaard, Lise ; Windirsch, Michael ; Scmiedeskamp, Jörg ; Heussel, Claus Peter ; Kauczor, Hans-Ulrich. / Assessment of lung microstructure with magnetic resonance imaging of hyperpolarized Helium-3. In: Respir Physiol Neurobiol. 2005 ; Vol. 148, No. 1-2. pp. 23-42.

Bibtex

@article{9f3f21b3f49743d697a83d21853f929b,
title = "Assessment of lung microstructure with magnetic resonance imaging of hyperpolarized Helium-3.",
abstract = "Magnetic resonance imaging of the apparent diffusion coefficient (ADC) of hyperpolarized Helium-3 is a new technique for probing pulmonary microstructure in vivo. The aim of this study was the assessment of potential sources of systematic errors of the ADC measurement. The influence of macroscopic motion was determined by measurements at two different delays after initiating the breath-hold, and before and after cardiac arrest. An intercentre comparison was performed in two age- and lung function-matched groups of lung-healthy volunteers at two research sites. Moreover, measurements of diffusion anisotropy were performed. We found no dependency of the ADC as a function of the delay after stop of inspiration. The influence of cardiac motion was less than 10%. In the intercentre comparison study, an excellent agreement between the two sites was found. First measurements of the diffusion tensor of intrapulmonary Helium-3 are shown",
author = "Schreiber, {Wolfgang G.} and Morbach, {Andreas E} and Trine Stavngaard and Gast, {Klaus K.} and Anette Herweling and Lise S{\o}gaard and Michael Windirsch and J{\"o}rg Scmiedeskamp and Heussel, {Claus Peter} and Hans-Ulrich Kauczor",
year = "2005",
language = "English",
volume = "148",
pages = "23--42",
journal = "Respiratory Physiology and Neurobiology",
issn = "1569-9048",
publisher = "Elsevier BV",
number = "1-2",

}

RIS

TY - JOUR

T1 - Assessment of lung microstructure with magnetic resonance imaging of hyperpolarized Helium-3.

AU - Schreiber, Wolfgang G.

AU - Morbach, Andreas E

AU - Stavngaard, Trine

AU - Gast, Klaus K.

AU - Herweling, Anette

AU - Søgaard, Lise

AU - Windirsch, Michael

AU - Scmiedeskamp, Jörg

AU - Heussel, Claus Peter

AU - Kauczor, Hans-Ulrich

PY - 2005

Y1 - 2005

N2 - Magnetic resonance imaging of the apparent diffusion coefficient (ADC) of hyperpolarized Helium-3 is a new technique for probing pulmonary microstructure in vivo. The aim of this study was the assessment of potential sources of systematic errors of the ADC measurement. The influence of macroscopic motion was determined by measurements at two different delays after initiating the breath-hold, and before and after cardiac arrest. An intercentre comparison was performed in two age- and lung function-matched groups of lung-healthy volunteers at two research sites. Moreover, measurements of diffusion anisotropy were performed. We found no dependency of the ADC as a function of the delay after stop of inspiration. The influence of cardiac motion was less than 10%. In the intercentre comparison study, an excellent agreement between the two sites was found. First measurements of the diffusion tensor of intrapulmonary Helium-3 are shown

AB - Magnetic resonance imaging of the apparent diffusion coefficient (ADC) of hyperpolarized Helium-3 is a new technique for probing pulmonary microstructure in vivo. The aim of this study was the assessment of potential sources of systematic errors of the ADC measurement. The influence of macroscopic motion was determined by measurements at two different delays after initiating the breath-hold, and before and after cardiac arrest. An intercentre comparison was performed in two age- and lung function-matched groups of lung-healthy volunteers at two research sites. Moreover, measurements of diffusion anisotropy were performed. We found no dependency of the ADC as a function of the delay after stop of inspiration. The influence of cardiac motion was less than 10%. In the intercentre comparison study, an excellent agreement between the two sites was found. First measurements of the diffusion tensor of intrapulmonary Helium-3 are shown

M3 - Journal article

VL - 148

SP - 23

EP - 42

JO - Respiratory Physiology and Neurobiology

JF - Respiratory Physiology and Neurobiology

SN - 1569-9048

IS - 1-2

ER -

ID: 32525103