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Assessment of lung microstructure with magnetic resonance imaging of hyperpolarized Helium-3.

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  1. Effect of pulmonary hyperinflation on central blood volume: An MRI study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Pulmonary capillary recruitment in response to hypoxia in healthy humans: a possible role for hypoxic pulmonary venoconstriction?

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Wolfgang G. Schreiber
  • Andreas E Morbach
  • Trine Stavngaard
  • Klaus K. Gast
  • Anette Herweling
  • Lise Søgaard
  • Michael Windirsch
  • Jörg Scmiedeskamp
  • Claus Peter Heussel
  • Hans-Ulrich Kauczor
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Magnetic resonance imaging of the apparent diffusion coefficient (ADC) of hyperpolarized Helium-3 is a new technique for probing pulmonary microstructure in vivo. The aim of this study was the assessment of potential sources of systematic errors of the ADC measurement. The influence of macroscopic motion was determined by measurements at two different delays after initiating the breath-hold, and before and after cardiac arrest. An intercentre comparison was performed in two age- and lung function-matched groups of lung-healthy volunteers at two research sites. Moreover, measurements of diffusion anisotropy were performed. We found no dependency of the ADC as a function of the delay after stop of inspiration. The influence of cardiac motion was less than 10%. In the intercentre comparison study, an excellent agreement between the two sites was found. First measurements of the diffusion tensor of intrapulmonary Helium-3 are shown
Original languageEnglish
JournalRespir Physiol Neurobiol
Volume148
Issue number1-2
Pages (from-to)23-42
Publication statusPublished - 2005

ID: 32525103