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Assessment of early diabetic renal changes with hyperpolarised [1-(13) C]pyruvate

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  1. Diabetes i familien – familien og diabetes

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  2. Diabetespatienter er afhængige af et løft af det nære sundhedsvæsen

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  3. Forord

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  4. Kun gode relationer kan nedbryde ’Sundhedsvæsnets Bermudatrekant’

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  5. Low serum adiponectin is associated with the metabolic syndrome and adds to cardiovascular risk in individuals with type 1 diabetes without nephropathy

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BAGGROUND: This experimental study explores a novel magnetic resonance imaging/spectroscopic (MRI/MRS) method that measures changes in renal metabolism in a diabetic rat model. This hyperpolarized metabolic MRI/MRS method allows monitoring of metabolic processes in seconds by >10,000-fold enhancement of the MR signal. The method has shown that the conversion of pyruvate to bicarbonate, i.e. pyruvate dehydrogenase (PDH) activity, is significantly altered in the myocardium already at the onset of diabetes, and the predominant Warburg effect is a valuable cancer maker via the lactate dehydrogenase (LDH) activity, and we hypothesize that a similar change in PDH and LDH could be found in the early diabetic kidney.
METHODS: In a streptozotocin rat model of type 1 diabetes, hyperpolarized (13) C-MRI and blood oxygenation level dependent (BOLD) (1) H-MRI was employed to investigate the changes in renal metabolism in the diabetic and the control kidney in vivo. RESULTS: The diabetic kidney showed a 149% increase in the lactate/pyruvate ratio compared to the control rat kidney, while the bicarbonate/pyruvate ratio was unchanged between the diabetic and the control rat kidney, consistent with literature findings. These metabolic findings paralleled a reduced intrarenal oxygen availability as found by BOLD MRI.
DISCUSSION: Hyperpolarized (13) C-MRI shows promise in the diagnosis and monitoring of early renal changes associated with diabetes, with the pyruvate/lactate ratio as an imaging biomarker for regional renal changes. Copyright © 2012 John Wiley & Sons, Ltd.
Original languageEnglish
JournalDiabetes - Metabolism: Research and Reviews (Online)
Volume29
Issue number2
Pages (from-to)125-9
Number of pages5
ISSN1520-7560
DOIs
Publication statusPublished - Feb 2013

ID: 36478835