Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital

Assessment of early diabetic renal changes with hyperpolarised [1-(13) C]pyruvate

Research output: Contribution to journalJournal articleResearchpeer-review


  1. Diabetes i familien – familien og diabetes

    Research output: Contribution to journalContribution to newspaper - Comment/debateCommunication

  2. Diabetespatienter er afhængige af et løft af det nære sundhedsvæsen

    Research output: Other contributionNet publication - Internet publicationCommunication

  3. Forord

    Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

  4. Kun gode relationer kan nedbryde ’Sundhedsvæsnets Bermudatrekant’

    Research output: Contribution to journalContribution to newspaper - Comment/debateCommunication

  5. Low serum adiponectin is associated with the metabolic syndrome and adds to cardiovascular risk in individuals with type 1 diabetes without nephropathy

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

View graph of relations
BAGGROUND: This experimental study explores a novel magnetic resonance imaging/spectroscopic (MRI/MRS) method that measures changes in renal metabolism in a diabetic rat model. This hyperpolarized metabolic MRI/MRS method allows monitoring of metabolic processes in seconds by >10,000-fold enhancement of the MR signal. The method has shown that the conversion of pyruvate to bicarbonate, i.e. pyruvate dehydrogenase (PDH) activity, is significantly altered in the myocardium already at the onset of diabetes, and the predominant Warburg effect is a valuable cancer maker via the lactate dehydrogenase (LDH) activity, and we hypothesize that a similar change in PDH and LDH could be found in the early diabetic kidney.
METHODS: In a streptozotocin rat model of type 1 diabetes, hyperpolarized (13) C-MRI and blood oxygenation level dependent (BOLD) (1) H-MRI was employed to investigate the changes in renal metabolism in the diabetic and the control kidney in vivo. RESULTS: The diabetic kidney showed a 149% increase in the lactate/pyruvate ratio compared to the control rat kidney, while the bicarbonate/pyruvate ratio was unchanged between the diabetic and the control rat kidney, consistent with literature findings. These metabolic findings paralleled a reduced intrarenal oxygen availability as found by BOLD MRI.
DISCUSSION: Hyperpolarized (13) C-MRI shows promise in the diagnosis and monitoring of early renal changes associated with diabetes, with the pyruvate/lactate ratio as an imaging biomarker for regional renal changes. Copyright © 2012 John Wiley & Sons, Ltd.
Original languageEnglish
JournalDiabetes - Metabolism: Research and Reviews (Online)
Issue number2
Pages (from-to)125-9
Number of pages5
Publication statusPublished - Feb 2013

ID: 36478835