Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Assessment of diurnal melatonin, cortisol, activity, and sleep-wake cycle in patients with and without diabetic retinopathy

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Mandibular advancement device therapy for obstructive sleep apnea: a prospective study on predictors of treatment success

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Melatonin and cortisol in individuals with spinal cord injury

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Restless legs syndrome is associated with major comorbidities in a population of Danish blood donors

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Flow cytometry analysis of T-cell subsets in cerebrospinal fluid of narcolepsy type 1 patients with long-lasting disease

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

OBJECTIVE: To assess the diurnal melatonin, cortisol, and activity/rest levels, as well as sleep quality, in patients with and without nonproliferative diabetic retinopathy (DR).

METHODS: We included 25 diabetic patients with DR and 29 without DR. A total of 21 healthy subjects constituted the control group. We assessed the circadian rhythm by actigraphy and diurnal salivary melatonin and cortisol measurements. Sleep quality was evaluated by actigraphy and the Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) questionnaires. Light exposure was quantified by actigraphy. The primary outcome was peak salivary melatonin level. Secondary outcomes were mean melatonin and cortisol levels during dark hours, activity-rest rhythm, sleep quality, as well as level of white, red, green, and blue light exposure.

RESULTS: Peak melatonin concentration at 04:00 and mean nocturnal melatonin level were significantly reduced in all diabetic patients, regardless of retinopathy stage (p < 0.001). Levels of light exposures during dark hours were not significantly different in patients with and without DR and healthy controls. Only patients with DR showed increased intradaily variability in their activity-rest interval, indicating circadian misalignment (p = 0.04). Neither the objective actigraphic sleep quality parameters nor the subjective PSQI or ESS scores were significantly different between healthy controls and diabetic patients.

CONCLUSIONS: Reduced nocturnal melatonin concentration and increased fragmentation of activity-rest intervals revealed circadian rhythm disturbance in diabetic patients with DR.

Original languageEnglish
JournalSleep Medicine
Volume54
Pages (from-to)35-42
Number of pages8
ISSN1389-9457
DOIs
Publication statusPublished - 1 Feb 2019

    Research areas

  • Actigraphy, Circadian rhythm, Diabetic retinopathy, Melatonin, PSQI, Sleep

ID: 56226930