Assessment of Disease Activity in Large-vessel Vasculitis: Results of an International Delphi Exercise

Sibel Z Aydin; Haner Direskeneli; Peter A Merkel; International Delphi on Disease Activity Assessment in Large-vessel Vasculitis (Bo Baslund, Mikkel Faurschou and others); Bo Baslund; Mikkel Faurschou

doi:10.3899/jrheum.161269

Assessment of Disease Activity in Large-vessel Vasculitis: Results of an International Delphi Exercise

Sibel Z Aydin, Haner Direskeneli, Peter A Merkel, International Delphi on Disease Activity Assessment in Large-vessel Vasculitis (Bo Baslund, Mikkel Faurschou and others), Bo Baslund (Member of study group), Mikkel Faurschou (Member of study group)

Department for Rheumatology and Spine Diseases

25 Citations (Scopus)

Abstract

OBJECTIVE: To arrive at consensus for candidate outcomes for disease activity assessment in large-vessel vasculitis (LVV) in clinical trials.

METHODS: A Delphi survey including 99 items was circulated among international experts for 3 rounds.

RESULTS: Fifty-seven items were accepted for both giant cell arteritis and Takayasu arteritis. Sixty-seven percent of experts voted to have a common approach for both diseases with additional disease-specific items such as weight loss, scalp tenderness/necrosis, morning stiffness, dizziness, visual symptoms, and imaging.

CONCLUSION: This study highlights similarities and differences in experts' perspectives for assessing clinical activity in LVV and may guide a consensus-driven core set of validated outcomes.

Original language	English
Journal	Journal of Rheumatology
Volume	44
Issue number	12
Pages (from-to)	1928-1932
Number of pages	5
ISSN	0315-162X
DOIs	https://doi.org/10.3899/jrheum.161269
Publication status	Published - Dec 2017

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Aydin, S. Z., Direskeneli, H., Merkel, P. A., International Delphi on Disease Activity Assessment in Large-vessel Vasculitis (Bo Baslund, Mikkel Faurschou and others), Baslund, B., & Faurschou, M. (2017). Assessment of Disease Activity in Large-vessel Vasculitis: Results of an International Delphi Exercise. Journal of Rheumatology, 44(12), 1928-1932. https://doi.org/10.3899/jrheum.161269

Aydin, SZ, Direskeneli, H, Merkel, PA, International Delphi on Disease Activity Assessment in Large-vessel Vasculitis (Bo Baslund, Mikkel Faurschou and others), Baslund, B & Faurschou, M 2017, 'Assessment of Disease Activity in Large-vessel Vasculitis: Results of an International Delphi Exercise', Journal of Rheumatology, vol. 44, no. 12, pp. 1928-1932. https://doi.org/10.3899/jrheum.161269

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AB - OBJECTIVE: To arrive at consensus for candidate outcomes for disease activity assessment in large-vessel vasculitis (LVV) in clinical trials.METHODS: A Delphi survey including 99 items was circulated among international experts for 3 rounds.RESULTS: Fifty-seven items were accepted for both giant cell arteritis and Takayasu arteritis. Sixty-seven percent of experts voted to have a common approach for both diseases with additional disease-specific items such as weight loss, scalp tenderness/necrosis, morning stiffness, dizziness, visual symptoms, and imaging.CONCLUSION: This study highlights similarities and differences in experts' perspectives for assessing clinical activity in LVV and may guide a consensus-driven core set of validated outcomes.

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Assessment of Disease Activity in Large-vessel Vasculitis: Results of an International Delphi Exercise

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