Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Assessing Impairment of Executive Function and Psychomotor Speed in Premanifest and Manifest Huntington's Disease Gene-expansion Carriers

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Confabulation Resilience of the Developing Brain: A Brief Review

    Research output: Contribution to journalReviewResearchpeer-review

  2. The bilingual effect on Boston Naming Test performance

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Enhancement of Autophagy and Solubilization of Ataxin-2 Alleviate Apoptosis in Spinocerebellar Ataxia Type 2 Patient Cells

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Early Intrathecal T Helper 17.1 Cell Activity in Huntington Disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Normative data for eight verbal fluency measures in older Danish adults

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Hereditære ataksier og sygdomme i det motoriske neuron

    Research output: Chapter in Book/Report/Conference proceedingBook chapterEducation

View graph of relations

Executive functions (EF) and psychomotor speed (PMS) has been widely studied in Huntington's disease (HD). Most studies have focused on finding markers of disease progression by comparing group means at different disease stages. Our aim was to investigate performances on nine measures of EF and PMS in a group of premanifest and manifest HD-gene expansion carriers and to investigate which measures were most sensitive for assessment of individual patients by analyzing frequencies of impaired performances relative to healthy controls. We recruited HD gene-expansion carriers, 48 manifest and 50 premanifest and as controls 39 healthy gene-expansion negative individuals. All participants underwent neurological examination and neuropsychological testing with nine cognitive measures. The frequency of impairment was investigated using cutoff scores. In group comparisons the manifest HD gene-expansion carriers scored significantly worse than controls on all tests and in classification of individual scores the majority of scores were classified as probably impaired (10th percentile) or impaired (5th percentile) with Symbol Digit Modalities Test (SDMT) being the most frequently impaired. Group comparisons of premanifest HD gene-expansion carriers and healthy controls showed significant differences on SDMT and Alternating fluency tests. Nevertheless the frequencies of probably impaired and impaired scores on individual tests were markedly higher for Alternating and Lexical fluency tests than for SDMT. We found distinct group differences in frequency of impairment on measures of EF and PMS in manifest and premanifest HD gene-expansion carriers. Our results indicate to what degree these measures can be expected to be clinically impaired. (JINS, 2015, 21, 1-10).

Original languageEnglish
JournalInternational Neuropsychological Society. Journal
Volume21
Issue number3
Pages (from-to)193-202
Number of pages10
ISSN1355-6177
DOIs
Publication statusPublished - 8 Apr 2015

ID: 45274585