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Arterial pressure during cardiopulmonary bypass is not associated with acute kidney injury

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@article{9e96b14bd37a4eb6870a38ecdf40cd93,
title = "Arterial pressure during cardiopulmonary bypass is not associated with acute kidney injury",
abstract = "BACKGROUND: Acute kidney injury (AKI) after cardiac surgery is common and is associated with increased mortality. We wanted to investigate if the arterial pressure or the use of norepinephrine during cardiopulmonary bypass were associated with AKI.METHODS: A retrospective analysis of patients who underwent coronary artery bypass grafting with or without concomitant procedures was conducted. AKI was defined using the RIFLE criteria. Data on arterial pressure and use of norepinephrine during cardiopulmonary bypass were entered in a binary logistic regression model to control for possible perioperative confounders.RESULTS: A total of 623 patients were included. Mean age was 68.3 ± 9.7 years and 81% were males. AKI was observed in 198 patients (32%). Mean arterial pressure was 47 ± 6 mmHg and 45 ± 6 mmHg (P = 0.008) in the AKI and no-AKI group, respectively. Norepinephrine was used more frequently and in higher amounts, during cardiopulmonary bypass, in patients who developed AKI. These differences in arterial pressures and use of norepinephrine between the groups were not found to be significant when entered in the binary logistic regression model.CONCLUSION: No independent relationship between arterial pressure or use of norepinephrine and AKI was found.",
keywords = "Acute Kidney Injury, Aged, Anesthesia, Arterial Pressure, Cardiopulmonary Bypass, Cardiotonic Agents, Comorbidity, Critical Care, Dose-Response Relationship, Drug, Female, Humans, Hypertension, Length of Stay, Male, Norepinephrine, Retrospective Studies, Vasoconstrictor Agents",
author = "K Kandler and Jensen, {M E} and Nilsson, {J C} and M{\o}ller, {C H} and Steinbr{\"u}chel, {D A}",
note = "{\textcopyright} 2015 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.",
year = "2015",
month = may,
doi = "10.1111/aas.12484",
language = "English",
volume = "59",
pages = "625--31",
journal = "Acta Anaesthesiologica Scandinavica",
issn = "0001-5172",
publisher = "Wiley-Blackwell Munksgaard",
number = "5",

}

RIS

TY - JOUR

T1 - Arterial pressure during cardiopulmonary bypass is not associated with acute kidney injury

AU - Kandler, K

AU - Jensen, M E

AU - Nilsson, J C

AU - Møller, C H

AU - Steinbrüchel, D A

N1 - © 2015 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

PY - 2015/5

Y1 - 2015/5

N2 - BACKGROUND: Acute kidney injury (AKI) after cardiac surgery is common and is associated with increased mortality. We wanted to investigate if the arterial pressure or the use of norepinephrine during cardiopulmonary bypass were associated with AKI.METHODS: A retrospective analysis of patients who underwent coronary artery bypass grafting with or without concomitant procedures was conducted. AKI was defined using the RIFLE criteria. Data on arterial pressure and use of norepinephrine during cardiopulmonary bypass were entered in a binary logistic regression model to control for possible perioperative confounders.RESULTS: A total of 623 patients were included. Mean age was 68.3 ± 9.7 years and 81% were males. AKI was observed in 198 patients (32%). Mean arterial pressure was 47 ± 6 mmHg and 45 ± 6 mmHg (P = 0.008) in the AKI and no-AKI group, respectively. Norepinephrine was used more frequently and in higher amounts, during cardiopulmonary bypass, in patients who developed AKI. These differences in arterial pressures and use of norepinephrine between the groups were not found to be significant when entered in the binary logistic regression model.CONCLUSION: No independent relationship between arterial pressure or use of norepinephrine and AKI was found.

AB - BACKGROUND: Acute kidney injury (AKI) after cardiac surgery is common and is associated with increased mortality. We wanted to investigate if the arterial pressure or the use of norepinephrine during cardiopulmonary bypass were associated with AKI.METHODS: A retrospective analysis of patients who underwent coronary artery bypass grafting with or without concomitant procedures was conducted. AKI was defined using the RIFLE criteria. Data on arterial pressure and use of norepinephrine during cardiopulmonary bypass were entered in a binary logistic regression model to control for possible perioperative confounders.RESULTS: A total of 623 patients were included. Mean age was 68.3 ± 9.7 years and 81% were males. AKI was observed in 198 patients (32%). Mean arterial pressure was 47 ± 6 mmHg and 45 ± 6 mmHg (P = 0.008) in the AKI and no-AKI group, respectively. Norepinephrine was used more frequently and in higher amounts, during cardiopulmonary bypass, in patients who developed AKI. These differences in arterial pressures and use of norepinephrine between the groups were not found to be significant when entered in the binary logistic regression model.CONCLUSION: No independent relationship between arterial pressure or use of norepinephrine and AKI was found.

KW - Acute Kidney Injury

KW - Aged

KW - Anesthesia

KW - Arterial Pressure

KW - Cardiopulmonary Bypass

KW - Cardiotonic Agents

KW - Comorbidity

KW - Critical Care

KW - Dose-Response Relationship, Drug

KW - Female

KW - Humans

KW - Hypertension

KW - Length of Stay

KW - Male

KW - Norepinephrine

KW - Retrospective Studies

KW - Vasoconstrictor Agents

U2 - 10.1111/aas.12484

DO - 10.1111/aas.12484

M3 - Journal article

C2 - 25882016

VL - 59

SP - 625

EP - 631

JO - Acta Anaesthesiologica Scandinavica

JF - Acta Anaesthesiologica Scandinavica

SN - 0001-5172

IS - 5

ER -

ID: 46170853