Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital

Arterial hypertension and morphologic abnormalities of cardiac chambers: results from the Copenhagen General Population Study

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Creatinine increase following initiation of antihypertensives is associated with cardiovascular risk: a nationwide cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Hypertension impairs hypoxia-induced angiogenesis in men

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Retinal arteriolar wall-to-lumen ratios at 16-17 years in the Copenhagen Child Cohort 2000 Study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

OBJECTIVES: In patients with arterial hypertension (AH), hypertension-mediated organ damage may be manifested by cardiac chamber enlargement and/or remodeling. Cardiac computed tomography imaging has emerged as an important method for morphological assessment of cardiac chambers. We tested the hypothesis that prevalence of cardiac chamber abnormalities is specifically related to clinical categories of AH in the general population. METHODS: We studied 4747 individuals, mean age was 60 years (range: 40-93), 46% were men, undergoing 320-detector computed tomography in the Copenhagen General Population Study. Clinical categories of AH were: normotensive (n = 2484), untreated hypertensive (n = 1301), treated controlled hypertensive (n = 412) and treated uncontrolled hypertensive (n = 550). Chamber abnormalities in the form of left ventricular (LV) concentric remodeling, LV eccentric hypertrophy, LV concentric hypertrophy or left atrial enlargement were assessed, in addition to LV or right ventricular enlargement. RESULTS: Chamber abnormalities were present in 23% of all individuals. Combined LV and left atrial abnormalities were rare (<2%). LV concentric remodeling (10%) was the most prevalent abnormality, and most commonly found in individuals with treated hypertension. LV and right ventricular enlargements were unrelated to hypertension. The highest frequencies of chamber abnormalities were found in individuals of elevated blood pressure (BP) with (40%) or without (32%) treatment, as opposed to individuals of normal BP with (27%) or without (14%) treatment, P less than 0.0001. CONCLUSION: In a general population cohort, untreated or inadequately treated AH was associated with the highest prevalence of cardiac chamber enlargement and remodeling. These observations suggest a strong link between elevated BPs and development of hypertension-mediated organ damage.

Original languageEnglish
JournalJournal of Hypertension
Issue number4
Pages (from-to)703-710
Number of pages8
Publication statusPublished - 1 Apr 2021

Bibliographical note

Publisher Copyright:
Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.

This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine

ID: 61650836