Are left ventricular mass, geometry and function related to vascular changes and/or insulin resistance in long-standing hypertension? ICARUS: a LIFE substudy

M H Olsen; E Hjerkinn; K Wachtell; A Høieggen; J N Bella; S D Nesbitt; E Fossum; S E Kjeldsen; S Julius; H Ibsen

doi:10.1038/sj.jhh.1001545

Are left ventricular mass, geometry and function related to vascular changes and/or insulin resistance in long-standing hypertension? ICARUS: a LIFE substudy

M H Olsen, E Hjerkinn, K Wachtell, A Høieggen, J N Bella, S D Nesbitt, E Fossum, S E Kjeldsen, S Julius, H Ibsen

Medicine Glostrup, Department of

13 Citations (Scopus)

Abstract

Vascular hypertrophy and insulin resistance have been associated with abnormal left ventricular (LV) geometry in population studies. We wanted to investigate the influence of vascular hypertrophy and insulin resistance on LV hypertrophy and its function in patients with hypertension. In 89 patients with essential hypertension and electrocardiographic LV hypertrophy, we measured blood pressure; insulin sensitivity by hyperinsulinaemic euglucaemic clamp; minimal forearm vascular resistance (MFVR) by plethysmography; intima-media cross-sectional area of the common carotid arteries (IMA) by ultrasound; and LV mass, relative wall thickness (RWT), systolic function and diastolic filling by echocardiography after two weeks of placebo treatment. LV mass index correlated to IMA/height (r=0.36, P=0.001), serum insulin (r=-0.25, P

Original language	English
Journal	Journal of Human Hypertension
Volume	17
Issue number	5
Pages (from-to)	305-11
Number of pages	7
ISSN	0950-9240
DOIs	https://doi.org/10.1038/sj.jhh.1001545
Publication status	Published - 2003

Keywords

Aged
Blood Flow Velocity
Blood Glucose
Blood Pressure
Carotid Artery, Common
Denmark
Diastole
Echocardiography
Female
Heart Ventricles
Humans
Hypertension
Hypertrophy, Left Ventricular
Insulin
Insulin Resistance
Male
Middle Aged
Norway
Sex Factors
Statistics as Topic
Stroke Volume
Systole
United States
Vascular Resistance
Ventricular Function, Left
Ventricular Remodeling

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10.1038/sj.jhh.1001545

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Olsen, M. H., Hjerkinn, E., Wachtell, K., Høieggen, A., Bella, J. N., Nesbitt, S. D., Fossum, E., Kjeldsen, S. E., Julius, S., & Ibsen, H. (2003). Are left ventricular mass, geometry and function related to vascular changes and/or insulin resistance in long-standing hypertension? ICARUS: a LIFE substudy. Journal of Human Hypertension, 17(5), 305-11. https://doi.org/10.1038/sj.jhh.1001545

Olsen, MH, Hjerkinn, E, Wachtell, K, Høieggen, A, Bella, JN, Nesbitt, SD, Fossum, E, Kjeldsen, SE, Julius, S & Ibsen, H 2003, 'Are left ventricular mass, geometry and function related to vascular changes and/or insulin resistance in long-standing hypertension? ICARUS: a LIFE substudy', Journal of Human Hypertension, vol. 17, no. 5, pp. 305-11. https://doi.org/10.1038/sj.jhh.1001545

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abstract = "Vascular hypertrophy and insulin resistance have been associated with abnormal left ventricular (LV) geometry in population studies. We wanted to investigate the influence of vascular hypertrophy and insulin resistance on LV hypertrophy and its function in patients with hypertension. In 89 patients with essential hypertension and electrocardiographic LV hypertrophy, we measured blood pressure; insulin sensitivity by hyperinsulinaemic euglucaemic clamp; minimal forearm vascular resistance (MFVR) by plethysmography; intima-media cross-sectional area of the common carotid arteries (IMA) by ultrasound; and LV mass, relative wall thickness (RWT), systolic function and diastolic filling by echocardiography after two weeks of placebo treatment. LV mass index correlated to IMA/height (r=0.36, P=0.001), serum insulin (r=-0.25, P",

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AU - Høieggen, A

AU - Bella, J N

AU - Nesbitt, S D

AU - Fossum, E

AU - Kjeldsen, S E

AU - Julius, S

AU - Ibsen, H

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KW - Heart Ventricles

KW - Humans

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KW - Insulin

KW - Insulin Resistance

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KW - Middle Aged

KW - Norway

KW - Sex Factors

KW - Statistics as Topic

KW - Stroke Volume

KW - Systole

KW - United States

KW - Vascular Resistance

KW - Ventricular Function, Left

KW - Ventricular Remodeling

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DO - 10.1038/sj.jhh.1001545

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JF - Journal of Human Hypertension

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ER -

Are left ventricular mass, geometry and function related to vascular changes and/or insulin resistance in long-standing hypertension? ICARUS: a LIFE substudy

Abstract

Keywords

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