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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Application of advanced brain positron emission tomography-based molecular imaging for a biological framework in neurodegenerative proteinopathies

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  1. European Ultrahigh-Field Imaging Network for Neurodegenerative Diseases (EUFIND)

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  2. Neuroimaging biomarkers for clinical trials in atypical parkinsonian disorders: Proposal for a Neuroimaging Biomarker Utility System

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  3. Evaluating combinations of diagnostic tests to discriminate different dementia types

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  1. Radiosynthesis and preclinical evaluation of [11 C]Cimbi-701 - Towards the imaging of cerebral 5-HT7 receptors

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  2. Optimization of preprocessing strategies in Positron Emission Tomography (PET) neuroimaging: A [11C]DASB PET study

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  3. One-Step Synthesis of N-Succinimidyl-4-[18F]Fluorobenzoate ([18F]SFB)

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  4. Development and Evaluation of Two Potential 5-HT7 Receptor PET Tracers: [18F]ENL09 and [18F]ENL10

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  5. Microdosing psychedelics: More questions than answers? An overview and suggestions for future research

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Introduction: A rapid transition from a clinical-based classification to a pathology-based classification of neurodegenerative conditions, largely promoted by the increasing availability of imaging biomarkers, is emerging. The Framework for Innovative Multi-tracer molecular Brain Imaging, funded by the EU Joint Program - Neurodegenerative Disease Research 2016 "Working Groups for Harmonisation and Alignment in Brain Imaging Methods for Neurodegeneration," aimed at providing a roadmap for the applications of established and new molecular imaging techniques in dementia.

Methods: We consider current and future implications of adopting a pathology-based framework for the use and development of positron emission tomography techniques.

Results: This approach will enhance efforts to understand the multifactorial etiology of Alzheimer's disease and other dementias.

Discussion: The availability of pathology biomarkers will soon transform clinical and research practice. Crucially, a comprehensive understanding of strengths and caveats of these techniques will promote an informed use to take full advantage of these tools.

Original languageEnglish
JournalAlzheimer's & dementia (Amsterdam, Netherlands)
Volume11
Pages (from-to)327-332
Number of pages6
ISSN2352-8729
DOIs
Publication statusPublished - Dec 2019

ID: 59321981