Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Apolipoprotein M/sphingosine-1-phosphate: novel effects on lipids, inflammation and kidney biology

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Remnant lipoproteins

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Relation between plasma and brain lipids

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Using human genetics to predict the effects and side-effects of drugs

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Novel genes in LDL metabolism--a comprehensive overview

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Apolipoprotein M in lipid metabolism and cardiometabolic diseases

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Apolipoprotein M-bound sphingosine-1-phosphate regulates blood-brain barrier paracellular permeability and transcytosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Long-acting neurotensin synergizes with liraglutide to reverse obesity through a Melanocortin-dependent pathway

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Diurnal regulation of sphingolipids in blood

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Subclinical atherosclerosis in patients with cyanotic congenital heart disease

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

PURPOSE OF REVIEW: In 2011, the crystal structure of apolipoprotein M (apoM) and its capacity to bind sphingosine-1-phosphate (S1P) was characterized. Since then, a variety of studies has increased our knowledge on apoM biology and functionality. From being an unknown and hardly significant player in overall metabolism, apoM has gained significant interest.

RECENT FINDINGS: Key discoveries in the last 2 years have indicated that the apoM/S1P complex has important roles in lipid metabolism (affecting triglyceride turnover), inflammation (a marker of severe sepsis and potentially providing anti-inflammatory signaling) and kidney biology (potential to protect against immunoglobulin A nephropathy).

SUMMARY: Several studies suggest a potential for apoM/S1P as biomarkers for inflammation, sepsis and nephropathy. Also, a novel chaperone is characterized and could have potential as a drug for treatment in inflammation and nephropathy.

Original languageEnglish
JournalCurrent Opinion in Lipidology
Volume30
Issue number3
Pages (from-to)212-217
Number of pages6
ISSN0957-9672
DOIs
Publication statusPublished - Jun 2019

ID: 58250424