Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Apelin is a novel islet peptide

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Gene expression profiling of gastric mucosa in mice lacking CCK and gastrin receptors

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Natriuretic peptides and cerebral hemodynamics

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Adropin: a new regulatory peptide in cardiovascular endocrinology

    Research output: Contribution to journalJournal articleResearch

  4. Cardiac C-type natriuretic peptide gene expression and plasma concentrations in neonatal piglets

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Gut hormones - Team workers or solo trippers?

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Oral D/L-3-Hydroxybutyrate stimulates cholecystokinin and insulin secretion and slows gastric emptying in healthy males

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Bilio-enteric flow and plasma concentrations of bile acids after gastric bypass and sleeve gastrectomy

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Circadian variations in plasma concentrations of cholecystokinin and gastrin in man

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Increased oral sodium chloride intake in humans amplifies selectively postprandial GLP-1 but not GIP, CCK, and gastrin in plasma

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations
Apelin, a recently discovered peptide with wide tissue distribution, regulates feeding behavior, improves glucose utilization, and inhibits insulin secretion. We examined whether apelin is expressed in human islets, as well as in normal and type 2 diabetic (T2D) animal islets. Further, we studied islet apelin regulation and the effect of apelin on insulin secretion. Apelin expression and regulation was examined in human and animal specimens using immunocytochemistry, in situ hybridization, and real-time PCR. Insulin secretion was studied in INS-1 (832/13) clonal beta cells. APJ-receptor expression was studied using real-time PCR. In human and murine islets apelin was predominantly expressed in beta cells and alpha cells; a subpopulation of the PP cells in human islets also harbored apelin. In porcine and feline islets apelin was mainly expressed in beta cells. APJ-receptor expression was detected in INS-1 (832/13) cells, and in human and mouse islets. A high dose (1microM) of apelin-36 caused a moderate increase in glucose-stimulated insulin secretion (30%; p
Original languageEnglish
JournalRegulatory Peptides
Volume162
Issue number1-3
Pages (from-to)44-51
Number of pages8
ISSN0167-0115
DOIs
Publication statusPublished - 8 Jun 2010

ID: 31034423