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The Capital Region of Denmark - a part of Copenhagen University Hospital
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α₁-Antitrypsin protease inhibitor MZ heterozygosity is associated with airflow obstruction in two large cohorts

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  1. International Severe Asthma Registry: Mission Statement

    Research output: Contribution to journalReviewResearchpeer-review

  2. Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children with asthma

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  3. An Integrative Transcriptomic and Metabolomic Study of Lung Function in Children With Asthma

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  4. Bariatric Surgery in Obese Patients With Psoriasis and COPD: Killing Three Birds With One Stone?

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  1. ERS and tobacco harm reduction

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  2. β2-Adrenergic genotypes and risk of severe exacerbations in COPD: a prospective cohort study

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  3. Prognostic significance of chronic respiratory symptoms in individuals with normal spirometry

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  4. Prognosis of COPD depends on severity of exacerbation history: A population-based analysis

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  • Inga-Cecilie Sørheim
  • Per Bakke
  • Amund Gulsvik
  • Sreekumar G Pillai
  • Ane Johannessen
  • Per I Gaarder
  • Edward J Campbell
  • Alvar Agustí
  • Peter M A Calverley
  • Claudio F Donner
  • Barry J Make
  • Stephen I Rennard
  • Jørgen Vestbo
  • Emiel F M Wouters
  • Peter D Paré
  • Robert D Levy
  • Harvey O Coxson
  • David A Lomas
  • Craig P Hersh
  • Edwin K Silverman
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Severe α₁-antitrypsin deficiency is a known genetic risk factor for COPD. Heterozygous (protease inhibitor [PI] MZ) individuals have moderately reduced serum levels of α₁-antitrypsin, but whether they have an increased risk of COPD is uncertain.
Original languageEnglish
JournalChest
Volume138
Issue number5
Pages (from-to)1125-32
Number of pages8
ISSN0012-3692
DOIs
Publication statusPublished - 1 Nov 2010

    Research areas

  • Aged, Airway Obstruction, Europe, Female, Forced Expiratory Volume, Genetic Predisposition to Disease, Heterozygote, Humans, Male, Middle Aged, North America, Norway, Pulmonary Disease, Chronic Obstructive, Risk Factors, alpha 1-Antitrypsin, alpha 1-Antitrypsin Deficiency

ID: 32722310