Abstract
We investigated antipyrine clearance and urinary excretion of 4-hydroxyantipyrine, 3-hydroxymethylantipyrine and nor-antipyrine in rats after 70% partial hepatectomy. Antipyrine clearance recovered more slowly than liver weight but after 240 h both liver weight and antipyrine clearance had reached control values. During hepatic regeneration conversion of antipyrine to the three major metabolites was reduced, conversion to 3-hydroxymethylantipyrine being reduced more than conversion to the other metabolites. Antipyrine clearance was closely correlated to liver weight (r = 0.81), indicating a close relation between the functional hepatic mass and the liver weight during hepatic regeneration.
| Original language | English |
|---|---|
| Journal | Liver |
| Volume | 5 |
| Issue number | 4 |
| Pages (from-to) | 196-9 |
| Number of pages | 4 |
| ISSN | 0106-9543 |
| DOIs | |
| Publication status | Published - Aug 1985 |
Keywords
- Animals
- Antipyrine/analogs & derivatives
- Edaravone
- Female
- Liver Diseases/metabolism
- Liver Regeneration
- Organ Size
- Rats
- Rats, Inbred Strains
- Time Factors
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