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Antipsychotic medication and remission of psychotic symptoms 10years after a first-episode psychosis

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@article{2786af020b9143c4a3b7f90612dd8f72,
title = "Antipsychotic medication and remission of psychotic symptoms 10years after a first-episode psychosis",
abstract = "BACKGROUND: Several national guidelines recommend continuous use of antipsychotic medication after a psychotic episode in order to minimize the risk of relapse. However some studies have identified a subgroup of patients who obtain remission of psychotic symptoms while not being on antipsychotic medication for a period of time. This study investigated the long-term outcome and characteristics of patients in remission of psychotic symptoms with no use of antipsychotic medication at the 10-year follow-up.METHODS: The study was a cohort study including 496 patients diagnosed with schizophrenia spectrum disorders (ICD 10: F20 and F22-29). Patients were included in the Danish OPUS Trial and followed up 10years after inclusion, where patient data was collected on socio-demographic factors, psychopathology, level of functioning and medication.FINDINGS: 61{\%} of the patients from the original cohort attended the 10-year follow up and 30{\%} of these had remission of psychotic symptoms at the time of the 10-year follow up with no current use of antipsychotic medication. This outcome was associated with female gender, high GAF-F score, participation in the labour market and absence of substance abuse.CONCLUSION: Our results describe a subgroup of patients who obtained remission while not being on antipsychotic medication at the 10-year follow-up. The finding calls for further investigation on a more individualized approach to long-term treatment with antipsychotic medication.",
keywords = "Journal Article",
author = "Wils, {Regitze S{\o}lling} and Gotfredsen, {Ditte Resendal} and Carsten Hjorth{\o}j and Austin, {Stephen F} and Nikolai Albert and Secher, {Rikke Gry} and Thorup, {Anne Amalie Elgaard} and Ole Mors and Merete Nordentoft",
note = "Copyright {\circledC} 2016 Elsevier B.V. All rights reserved.",
year = "2017",
month = "4",
doi = "10.1016/j.schres.2016.10.030",
language = "English",
volume = "182",
pages = "42--48",
journal = "Schizophrenia Research",
issn = "0920-9964",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Antipsychotic medication and remission of psychotic symptoms 10years after a first-episode psychosis

AU - Wils, Regitze Sølling

AU - Gotfredsen, Ditte Resendal

AU - Hjorthøj, Carsten

AU - Austin, Stephen F

AU - Albert, Nikolai

AU - Secher, Rikke Gry

AU - Thorup, Anne Amalie Elgaard

AU - Mors, Ole

AU - Nordentoft, Merete

N1 - Copyright © 2016 Elsevier B.V. All rights reserved.

PY - 2017/4

Y1 - 2017/4

N2 - BACKGROUND: Several national guidelines recommend continuous use of antipsychotic medication after a psychotic episode in order to minimize the risk of relapse. However some studies have identified a subgroup of patients who obtain remission of psychotic symptoms while not being on antipsychotic medication for a period of time. This study investigated the long-term outcome and characteristics of patients in remission of psychotic symptoms with no use of antipsychotic medication at the 10-year follow-up.METHODS: The study was a cohort study including 496 patients diagnosed with schizophrenia spectrum disorders (ICD 10: F20 and F22-29). Patients were included in the Danish OPUS Trial and followed up 10years after inclusion, where patient data was collected on socio-demographic factors, psychopathology, level of functioning and medication.FINDINGS: 61% of the patients from the original cohort attended the 10-year follow up and 30% of these had remission of psychotic symptoms at the time of the 10-year follow up with no current use of antipsychotic medication. This outcome was associated with female gender, high GAF-F score, participation in the labour market and absence of substance abuse.CONCLUSION: Our results describe a subgroup of patients who obtained remission while not being on antipsychotic medication at the 10-year follow-up. The finding calls for further investigation on a more individualized approach to long-term treatment with antipsychotic medication.

AB - BACKGROUND: Several national guidelines recommend continuous use of antipsychotic medication after a psychotic episode in order to minimize the risk of relapse. However some studies have identified a subgroup of patients who obtain remission of psychotic symptoms while not being on antipsychotic medication for a period of time. This study investigated the long-term outcome and characteristics of patients in remission of psychotic symptoms with no use of antipsychotic medication at the 10-year follow-up.METHODS: The study was a cohort study including 496 patients diagnosed with schizophrenia spectrum disorders (ICD 10: F20 and F22-29). Patients were included in the Danish OPUS Trial and followed up 10years after inclusion, where patient data was collected on socio-demographic factors, psychopathology, level of functioning and medication.FINDINGS: 61% of the patients from the original cohort attended the 10-year follow up and 30% of these had remission of psychotic symptoms at the time of the 10-year follow up with no current use of antipsychotic medication. This outcome was associated with female gender, high GAF-F score, participation in the labour market and absence of substance abuse.CONCLUSION: Our results describe a subgroup of patients who obtained remission while not being on antipsychotic medication at the 10-year follow-up. The finding calls for further investigation on a more individualized approach to long-term treatment with antipsychotic medication.

KW - Journal Article

U2 - 10.1016/j.schres.2016.10.030

DO - 10.1016/j.schres.2016.10.030

M3 - Journal article

VL - 182

SP - 42

EP - 48

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

ER -

ID: 51549142