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Antimicrobial Tolerance and Metabolic Adaptations in Microbial Biofilms

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@article{eefebccdaede4ec59ec836073a3d1949,
title = "Antimicrobial Tolerance and Metabolic Adaptations in Microbial Biofilms",
abstract = "Active bacterial metabolism is a prerequisite for optimal activity of many classes of antibiotics. Hence, bacteria have developed strategies to reduce or modulate metabolic pathways to become tolerant. This review describes the tight relationship between metabolism and tolerance in bacterial biofilms, and how physicochemical properties of the microenvironment at the host-pathogen interface (such as oxygen and nutritional content) are key to this relationship. Understanding how metabolic adaptations lead to tolerance brings us to novel approaches to tackle antibiotic-tolerant biofilms. We describe the use of hyperbaric oxygen therapy, metabolism-stimulating metabolites, and alternative strategies to redirect bacterial metabolism towards an antibiotic-susceptible phenotype.",
author = "Aur{\'e}lie Crabb{\'e} and Jensen, {Peter {\O}strup} and Thomas Bjarnsholt and Tom Coenye",
note = "Copyright {\circledC} 2019 Elsevier Ltd. All rights reserved.",
year = "2019",
month = "10",
doi = "10.1016/j.tim.2019.05.003",
language = "English",
volume = "27",
pages = "850--863",
journal = "Trends in Microbiology",
issn = "0966-842X",
publisher = "Elsevier Ltd. Trends Journals",
number = "10",

}

RIS

TY - JOUR

T1 - Antimicrobial Tolerance and Metabolic Adaptations in Microbial Biofilms

AU - Crabbé, Aurélie

AU - Jensen, Peter Østrup

AU - Bjarnsholt, Thomas

AU - Coenye, Tom

N1 - Copyright © 2019 Elsevier Ltd. All rights reserved.

PY - 2019/10

Y1 - 2019/10

N2 - Active bacterial metabolism is a prerequisite for optimal activity of many classes of antibiotics. Hence, bacteria have developed strategies to reduce or modulate metabolic pathways to become tolerant. This review describes the tight relationship between metabolism and tolerance in bacterial biofilms, and how physicochemical properties of the microenvironment at the host-pathogen interface (such as oxygen and nutritional content) are key to this relationship. Understanding how metabolic adaptations lead to tolerance brings us to novel approaches to tackle antibiotic-tolerant biofilms. We describe the use of hyperbaric oxygen therapy, metabolism-stimulating metabolites, and alternative strategies to redirect bacterial metabolism towards an antibiotic-susceptible phenotype.

AB - Active bacterial metabolism is a prerequisite for optimal activity of many classes of antibiotics. Hence, bacteria have developed strategies to reduce or modulate metabolic pathways to become tolerant. This review describes the tight relationship between metabolism and tolerance in bacterial biofilms, and how physicochemical properties of the microenvironment at the host-pathogen interface (such as oxygen and nutritional content) are key to this relationship. Understanding how metabolic adaptations lead to tolerance brings us to novel approaches to tackle antibiotic-tolerant biofilms. We describe the use of hyperbaric oxygen therapy, metabolism-stimulating metabolites, and alternative strategies to redirect bacterial metabolism towards an antibiotic-susceptible phenotype.

U2 - 10.1016/j.tim.2019.05.003

DO - 10.1016/j.tim.2019.05.003

M3 - Review

VL - 27

SP - 850

EP - 863

JO - Trends in Microbiology

JF - Trends in Microbiology

SN - 0966-842X

IS - 10

ER -

ID: 58994800