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Anti-gravity training improves walking capacity and postural balance in patients with muscular dystrophy

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  1. Results of an open label feasibility study of sodium valproate in people with McArdle disease

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  2. Contractile properties are impaired in congenital myopathies

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  3. No effect of oral sucrose or IV glucose during exercise in phosphorylase b kinase deficiency

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  4. MYO-MRI diagnostic protocols in genetic myopathies

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  1. Phenotypic Spectrum of α-Dystroglycanopathies Associated With the c.919T>a Variant in the FKRP Gene in Humans and Mice

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  2. Data from the European registry for patients with McArdle disease and other muscle glycogenoses (EUROMAC)

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  3. Creation and implementation of a European registry for patients with McArdle disease and other muscle glycogenoses (EUROMAC registry)

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  4. Bimagrumab vs Optimized Standard of Care for Treatment of Sarcopenia in Community-Dwelling Older Adults: A Randomized Clinical Trial

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  5. Vacuoles, Often Containing Glycogen, Are a Consistent Finding in Hypokalemic Periodic Paralysis

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Recent studies in patients with muscular dystrophies suggest positive effects of aerobic and strength training. These studies focused training on using bicycle ergometers and conventional strength training, which precludes more severely affected patients from participating, because of their weakness. We investigated the functional effects of combined aerobic and strength training in patients with Becker and limb-girdle muscular dystrophies with knee muscle strength levels as low as 3% of normal strength. Eight patients performed 10 weeks of aerobic and strength training on an anti-gravity treadmill, which offered weight support up to 80% of their body weight. Six minute walking distance, dynamic postural balance, and plasma creatine kinase were assessed 10 weeks prior to training, immediately before training and after 10 weeks of training. Training elicited an improvement of walking distance by 8±2% and dynamic postural balance by 13±4%, indicating an improved physical function. Plasma creatine kinase remained unchanged. These results provide evidence that a combination of aerobic and strength training during anti-gravity has the potential to safely improve functional ability in severely affected patients with Becker and limb-girdle muscular dystrophies.

Original languageEnglish
JournalNeuromuscular disorders : NMD
Volume24
Issue number6
Pages (from-to)492-8
Number of pages7
ISSN0960-8966
DOIs
Publication statusPublished - Jun 2014

    Research areas

  • Adult, Exercise Therapy, Female, Gravity, Altered, Humans, Male, Middle Aged, Muscular Dystrophies, Postural Balance, Walking

ID: 44995574