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Anti-dopamine D2 receptor antibodies in chronic tic disorders

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Harvard

Addabbo, F, Baglioni, V, Schrag, A, Schwarz, MJ, Dietrich, A, Hoekstra, PJ, Martino, D, Buttiglione, M & EMTICS Collaborative Group 2020, 'Anti-dopamine D2 receptor antibodies in chronic tic disorders', Developmental Medicine and Child Neurology, vol. 62, no. 10, pp. 1205-1212. https://doi.org/10.1111/dmcn.14613

APA

Addabbo, F., Baglioni, V., Schrag, A., Schwarz, M. J., Dietrich, A., Hoekstra, P. J., Martino, D., Buttiglione, M., & EMTICS Collaborative Group (2020). Anti-dopamine D2 receptor antibodies in chronic tic disorders. Developmental Medicine and Child Neurology, 62(10), 1205-1212. https://doi.org/10.1111/dmcn.14613

CBE

Addabbo F, Baglioni V, Schrag A, Schwarz MJ, Dietrich A, Hoekstra PJ, Martino D, Buttiglione M, EMTICS Collaborative Group. 2020. Anti-dopamine D2 receptor antibodies in chronic tic disorders. Developmental Medicine and Child Neurology. 62(10):1205-1212. https://doi.org/10.1111/dmcn.14613

MLA

Vancouver

Addabbo F, Baglioni V, Schrag A, Schwarz MJ, Dietrich A, Hoekstra PJ et al. Anti-dopamine D2 receptor antibodies in chronic tic disorders. Developmental Medicine and Child Neurology. 2020 Oct;62(10):1205-1212. https://doi.org/10.1111/dmcn.14613

Author

Addabbo, Francesco ; Baglioni, Valentina ; Schrag, Anette ; Schwarz, Markus J ; Dietrich, Andrea ; Hoekstra, Pieter J ; Martino, Davide ; Buttiglione, Maura ; EMTICS Collaborative Group. / Anti-dopamine D2 receptor antibodies in chronic tic disorders. In: Developmental Medicine and Child Neurology. 2020 ; Vol. 62, No. 10. pp. 1205-1212.

Bibtex

@article{a67441ec2db24f03a976956e8016dfa1,
title = "Anti-dopamine D2 receptor antibodies in chronic tic disorders",
abstract = "AIM: To investigate the association between circulating anti-dopamine D2 receptor (D2R) autoantibodies and the exacerbation of tics in children with chronic tic disorders (CTDs).METHOD: One hundred and thirty-seven children with CTDs (108 males, 29 females; mean age [SD] 10y 0mo [2y 7mo], range 4-16y) were recruited over 18 months. Patients were assessed at baseline, at tic exacerbation, and at 2 months after exacerbation. Serum anti-D2R antibodies were evaluated using a cell-based assay and blinded immunofluorescence microscopy scoring was performed by two raters. The association between visit type and presence of anti-D2R antibodies was measured with McNemar's test and repeated-measure logistic regression models, adjusting for potential demographic and clinical confounders.RESULTS: At exacerbation, 11 (8%) participants became anti-D2R-positive ('early peri-exacerbation seroconverters'), and nine (6.6%) became anti-D2R-positive at post-exacerbation ('late peri-exacerbation seroconverters'). The anti-D2R antibodies were significantly associated with exacerbations when compared to baseline (McNemar's odds ratio=11, p=0.003) and conditional logistic regression confirmed this association (Z=3.49, p<0.001) after adjustment for demographic and clinical data and use of psychotropic drugs.INTERPRETATION: There is a potential association between immune mechanisms and the severity course of tics in adolescents with CTDs.",
keywords = "Adolescent, Autoantibodies/blood, Child, Child, Preschool, Female, Humans, Male, Receptors, Dopamine D2/immunology, Tic Disorders/blood",
author = "Francesco Addabbo and Valentina Baglioni and Anette Schrag and Schwarz, {Markus J} and Andrea Dietrich and Hoekstra, {Pieter J} and Davide Martino and Maura Buttiglione and {EMTICS Collaborative Group} and Julie Hagstr{\o}m and Liselotte Skov and Debes, {Nanette Marinette Monique Mol}",
note = "{\textcopyright} 2020 Mac Keith Press.",
year = "2020",
month = oct,
doi = "10.1111/dmcn.14613",
language = "English",
volume = "62",
pages = "1205--1212",
journal = "Developmental Medicine and Child Neurology",
issn = "0012-1622",
publisher = "Mac Keith Press",
number = "10",

}

RIS

TY - JOUR

T1 - Anti-dopamine D2 receptor antibodies in chronic tic disorders

AU - Addabbo, Francesco

AU - Baglioni, Valentina

AU - Schrag, Anette

AU - Schwarz, Markus J

AU - Dietrich, Andrea

AU - Hoekstra, Pieter J

AU - Martino, Davide

AU - Buttiglione, Maura

AU - EMTICS Collaborative Group

A2 - Hagstrøm, Julie

A2 - Skov, Liselotte

A2 - Debes, Nanette Marinette Monique Mol

N1 - © 2020 Mac Keith Press.

PY - 2020/10

Y1 - 2020/10

N2 - AIM: To investigate the association between circulating anti-dopamine D2 receptor (D2R) autoantibodies and the exacerbation of tics in children with chronic tic disorders (CTDs).METHOD: One hundred and thirty-seven children with CTDs (108 males, 29 females; mean age [SD] 10y 0mo [2y 7mo], range 4-16y) were recruited over 18 months. Patients were assessed at baseline, at tic exacerbation, and at 2 months after exacerbation. Serum anti-D2R antibodies were evaluated using a cell-based assay and blinded immunofluorescence microscopy scoring was performed by two raters. The association between visit type and presence of anti-D2R antibodies was measured with McNemar's test and repeated-measure logistic regression models, adjusting for potential demographic and clinical confounders.RESULTS: At exacerbation, 11 (8%) participants became anti-D2R-positive ('early peri-exacerbation seroconverters'), and nine (6.6%) became anti-D2R-positive at post-exacerbation ('late peri-exacerbation seroconverters'). The anti-D2R antibodies were significantly associated with exacerbations when compared to baseline (McNemar's odds ratio=11, p=0.003) and conditional logistic regression confirmed this association (Z=3.49, p<0.001) after adjustment for demographic and clinical data and use of psychotropic drugs.INTERPRETATION: There is a potential association between immune mechanisms and the severity course of tics in adolescents with CTDs.

AB - AIM: To investigate the association between circulating anti-dopamine D2 receptor (D2R) autoantibodies and the exacerbation of tics in children with chronic tic disorders (CTDs).METHOD: One hundred and thirty-seven children with CTDs (108 males, 29 females; mean age [SD] 10y 0mo [2y 7mo], range 4-16y) were recruited over 18 months. Patients were assessed at baseline, at tic exacerbation, and at 2 months after exacerbation. Serum anti-D2R antibodies were evaluated using a cell-based assay and blinded immunofluorescence microscopy scoring was performed by two raters. The association between visit type and presence of anti-D2R antibodies was measured with McNemar's test and repeated-measure logistic regression models, adjusting for potential demographic and clinical confounders.RESULTS: At exacerbation, 11 (8%) participants became anti-D2R-positive ('early peri-exacerbation seroconverters'), and nine (6.6%) became anti-D2R-positive at post-exacerbation ('late peri-exacerbation seroconverters'). The anti-D2R antibodies were significantly associated with exacerbations when compared to baseline (McNemar's odds ratio=11, p=0.003) and conditional logistic regression confirmed this association (Z=3.49, p<0.001) after adjustment for demographic and clinical data and use of psychotropic drugs.INTERPRETATION: There is a potential association between immune mechanisms and the severity course of tics in adolescents with CTDs.

KW - Adolescent

KW - Autoantibodies/blood

KW - Child

KW - Child, Preschool

KW - Female

KW - Humans

KW - Male

KW - Receptors, Dopamine D2/immunology

KW - Tic Disorders/blood

U2 - 10.1111/dmcn.14613

DO - 10.1111/dmcn.14613

M3 - Journal article

C2 - 32644201

VL - 62

SP - 1205

EP - 1212

JO - Developmental Medicine and Child Neurology

JF - Developmental Medicine and Child Neurology

SN - 0012-1622

IS - 10

ER -

ID: 62293560