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Anti-dopamine D2 receptor antibodies in chronic tic disorders

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  • Francesco Addabbo
  • Valentina Baglioni
  • Anette Schrag
  • Markus J Schwarz
  • Andrea Dietrich
  • Pieter J Hoekstra
  • Davide Martino
  • Maura Buttiglione
  • EMTICS Collaborative Group
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AIM: To investigate the association between circulating anti-dopamine D2 receptor (D2R) autoantibodies and the exacerbation of tics in children with chronic tic disorders (CTDs).

METHOD: One hundred and thirty-seven children with CTDs (108 males, 29 females; mean age [SD] 10y 0mo [2y 7mo], range 4-16y) were recruited over 18 months. Patients were assessed at baseline, at tic exacerbation, and at 2 months after exacerbation. Serum anti-D2R antibodies were evaluated using a cell-based assay and blinded immunofluorescence microscopy scoring was performed by two raters. The association between visit type and presence of anti-D2R antibodies was measured with McNemar's test and repeated-measure logistic regression models, adjusting for potential demographic and clinical confounders.

RESULTS: At exacerbation, 11 (8%) participants became anti-D2R-positive ('early peri-exacerbation seroconverters'), and nine (6.6%) became anti-D2R-positive at post-exacerbation ('late peri-exacerbation seroconverters'). The anti-D2R antibodies were significantly associated with exacerbations when compared to baseline (McNemar's odds ratio=11, p=0.003) and conditional logistic regression confirmed this association (Z=3.49, p<0.001) after adjustment for demographic and clinical data and use of psychotropic drugs.

INTERPRETATION: There is a potential association between immune mechanisms and the severity course of tics in adolescents with CTDs.

Original languageEnglish
JournalDevelopmental Medicine and Child Neurology
Volume62
Issue number10
Pages (from-to)1205-1212
Number of pages8
ISSN0012-1622
DOIs
Publication statusPublished - Oct 2020

    Research areas

  • Adolescent, Autoantibodies/blood, Child, Child, Preschool, Female, Humans, Male, Receptors, Dopamine D2/immunology, Tic Disorders/blood

ID: 62293560