Antibodies to expanded virus antigen panels show elevated diagnostic sensitivities in multiple sclerosis and optic neuritis

Helena Gåsland; Nicole H Trier; Cecilie Kyllesbech; Anette H Draborg; Rimantas Slibinskas; Evaldas Ciplys; Jette L Frederiksen; Gunnar Houen

doi:10.1016/j.imlet.2023.02.003

Antibodies to expanded virus antigen panels show elevated diagnostic sensitivities in multiple sclerosis and optic neuritis

Helena Gåsland, Nicole H Trier, Cecilie Kyllesbech, Anette H Draborg, Rimantas Slibinskas, Evaldas Ciplys, Jette L Frederiksen, Gunnar Houen^*

^*Corresponding author for this work

Department of Neurology

6 Citations (Scopus)

Abstract

An antigen panel consisting of Epstein-Barr, measles, mumps, varicella zoster and rubella viruses (EMMRZ) was recently presented, which may aid in the diagnosis of multiple sclerosis (MS). The aim of this study was to validate and extend the EMMRZ panel. Various candidates, such as Cytomegalovirus and John Cunningham virus were analysed in relapsing-remitting MS (RRMS) and optic neuritis (ON) samples by enzyme-linked immunosorbent assay. IgG levels were elevated in RRMS samples and correlations were found between serum and cerebrospinal fluid levels. Cohort-dependent optimized panels were obtained for RRMS and ON, which obtained the highest sensitivity when combined with the status of oligoclonal bands.

Original language	English
Journal	Immunology Letters
Volume	254
Pages (from-to)	54-64
Number of pages	11
ISSN	0165-2478
DOIs	https://doi.org/10.1016/j.imlet.2023.02.003
Publication status	Published - Feb 2023

Keywords

Antibodies, Viral
Antigens, Viral
Humans
Immunoglobulin G
Multiple Sclerosis
Multiple Sclerosis, Relapsing-Remitting
Optic Neuritis
Multiple sclerosis
Antibody index
Optic neuritis
Antibodies
Antibody correlations
Virus antigens

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10.1016/j.imlet.2023.02.003

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@article{ba1eb3eb27564c41ba6a8c05cdbc6bbb,

title = "Antibodies to expanded virus antigen panels show elevated diagnostic sensitivities in multiple sclerosis and optic neuritis",

abstract = "An antigen panel consisting of Epstein-Barr, measles, mumps, varicella zoster and rubella viruses (EMMRZ) was recently presented, which may aid in the diagnosis of multiple sclerosis (MS). The aim of this study was to validate and extend the EMMRZ panel. Various candidates, such as Cytomegalovirus and John Cunningham virus were analysed in relapsing-remitting MS (RRMS) and optic neuritis (ON) samples by enzyme-linked immunosorbent assay. IgG levels were elevated in RRMS samples and correlations were found between serum and cerebrospinal fluid levels. Cohort-dependent optimized panels were obtained for RRMS and ON, which obtained the highest sensitivity when combined with the status of oligoclonal bands.",

keywords = "Antibodies, Viral, Antigens, Viral, Humans, Immunoglobulin G, Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting, Optic Neuritis, Multiple sclerosis, Antibody index, Optic neuritis, Antibodies, Antibody correlations, Virus antigens",

author = "Helena G{\aa}sland and Trier, \{Nicole H\} and Cecilie Kyllesbech and Draborg, \{Anette H\} and Rimantas Slibinskas and Evaldas Ciplys and Frederiksen, \{Jette L\} and Gunnar Houen",

note = "Copyright {\textcopyright} 2023. Published by Elsevier B.V.",

year = "2023",

month = feb,

doi = "10.1016/j.imlet.2023.02.003",

language = "English",

volume = "254",

pages = "54--64",

journal = "Immunology Letters",

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publisher = "Elsevier BV",

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TY - JOUR

T1 - Antibodies to expanded virus antigen panels show elevated diagnostic sensitivities in multiple sclerosis and optic neuritis

AU - Gåsland, Helena

AU - Trier, Nicole H

AU - Kyllesbech, Cecilie

AU - Draborg, Anette H

AU - Slibinskas, Rimantas

AU - Ciplys, Evaldas

AU - Frederiksen, Jette L

AU - Houen, Gunnar

PY - 2023/2

Y1 - 2023/2

N2 - An antigen panel consisting of Epstein-Barr, measles, mumps, varicella zoster and rubella viruses (EMMRZ) was recently presented, which may aid in the diagnosis of multiple sclerosis (MS). The aim of this study was to validate and extend the EMMRZ panel. Various candidates, such as Cytomegalovirus and John Cunningham virus were analysed in relapsing-remitting MS (RRMS) and optic neuritis (ON) samples by enzyme-linked immunosorbent assay. IgG levels were elevated in RRMS samples and correlations were found between serum and cerebrospinal fluid levels. Cohort-dependent optimized panels were obtained for RRMS and ON, which obtained the highest sensitivity when combined with the status of oligoclonal bands.

AB - An antigen panel consisting of Epstein-Barr, measles, mumps, varicella zoster and rubella viruses (EMMRZ) was recently presented, which may aid in the diagnosis of multiple sclerosis (MS). The aim of this study was to validate and extend the EMMRZ panel. Various candidates, such as Cytomegalovirus and John Cunningham virus were analysed in relapsing-remitting MS (RRMS) and optic neuritis (ON) samples by enzyme-linked immunosorbent assay. IgG levels were elevated in RRMS samples and correlations were found between serum and cerebrospinal fluid levels. Cohort-dependent optimized panels were obtained for RRMS and ON, which obtained the highest sensitivity when combined with the status of oligoclonal bands.

KW - Antibodies, Viral

KW - Antigens, Viral

KW - Humans

KW - Immunoglobulin G

KW - Multiple Sclerosis

KW - Multiple Sclerosis, Relapsing-Remitting

KW - Optic Neuritis

KW - Multiple sclerosis

KW - Antibody index

KW - Optic neuritis

KW - Antibodies

KW - Antibody correlations

KW - Virus antigens

UR - https://www.scopus.com/pages/publications/85147858594

UR - https://www.sciencedirect.com/science/article/pii/S0165247825001002?via%3Dihub

U2 - 10.1016/j.imlet.2023.02.003

DO - 10.1016/j.imlet.2023.02.003

M3 - Journal article

C2 - 36764611

SN - 0165-2478

VL - 254

SP - 54

EP - 64

JO - Immunology Letters

JF - Immunology Letters

ER -

Antibodies to expanded virus antigen panels show elevated diagnostic sensitivities in multiple sclerosis and optic neuritis

Abstract

Keywords

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