Antibodies to expanded virus antigen panels show elevated diagnostic sensitivities in multiple sclerosis and optic neuritis

Helena Gåsland; Nicole H Trier; Cecilie Kyllesbech; Anette H Draborg; Rimantas Slibinskas; Evaldas Ciplys; Jette L Frederiksen; Gunnar Houen

doi:10.1016/j.imlet.2023.02.003

Antibodies to expanded virus antigen panels show elevated diagnostic sensitivities in multiple sclerosis and optic neuritis

Helena Gåsland, Nicole H Trier, Cecilie Kyllesbech, Anette H Draborg, Rimantas Slibinskas, Evaldas Ciplys, Jette L Frederiksen, Gunnar Houen^*

^*Corresponding author for this work

Department of Neurology

Abstract

An antigen panel consisting of Epstein-Barr, measles, mumps, varicella zoster and rubella viruses (EMMRZ) was recently presented, which may aid in the diagnosis of multiple sclerosis (MS). The aim of this study was to validate and extend the EMMRZ panel. Various candidates, such as Cytomegalovirus and John Cunningham virus were analysed in relapsing-remitting MS (RRMS) and optic neuritis (ON) samples by enzyme-linked immunosorbent assay. IgG levels were elevated in RRMS samples and correlations were found between serum and cerebrospinal fluid levels. Cohort-dependent optimized panels were obtained for RRMS and ON, which obtained the highest sensitivity when combined with the status of oligoclonal bands.

Original language	English
Journal	Immunology Letters
Volume	254
Pages (from-to)	54-64
Number of pages	11
ISSN	0165-2478
DOIs	https://doi.org/10.1016/j.imlet.2023.02.003
Publication status	Published - 2023

Access to Document

10.1016/j.imlet.2023.02.003

Cite this

@article{ba1eb3eb27564c41ba6a8c05cdbc6bbb,

title = "Antibodies to expanded virus antigen panels show elevated diagnostic sensitivities in multiple sclerosis and optic neuritis",

abstract = "An antigen panel consisting of Epstein-Barr, measles, mumps, varicella zoster and rubella viruses (EMMRZ) was recently presented, which may aid in the diagnosis of multiple sclerosis (MS). The aim of this study was to validate and extend the EMMRZ panel. Various candidates, such as Cytomegalovirus and John Cunningham virus were analysed in relapsing-remitting MS (RRMS) and optic neuritis (ON) samples by enzyme-linked immunosorbent assay. IgG levels were elevated in RRMS samples and correlations were found between serum and cerebrospinal fluid levels. Cohort-dependent optimized panels were obtained for RRMS and ON, which obtained the highest sensitivity when combined with the status of oligoclonal bands.",

author = "Helena G{\aa}sland and Trier, {Nicole H} and Cecilie Kyllesbech and Draborg, {Anette H} and Rimantas Slibinskas and Evaldas Ciplys and Frederiksen, {Jette L} and Gunnar Houen",

note = "Copyright {\textcopyright} 2023. Published by Elsevier B.V.",

year = "2023",

doi = "10.1016/j.imlet.2023.02.003",

language = "English",

volume = "254",

pages = "54--64",

journal = "Immunology Letters",

issn = "0165-2478",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - Antibodies to expanded virus antigen panels show elevated diagnostic sensitivities in multiple sclerosis and optic neuritis

AU - Gåsland, Helena

AU - Trier, Nicole H

AU - Kyllesbech, Cecilie

AU - Draborg, Anette H

AU - Slibinskas, Rimantas

AU - Ciplys, Evaldas

AU - Frederiksen, Jette L

AU - Houen, Gunnar

PY - 2023

Y1 - 2023

N2 - An antigen panel consisting of Epstein-Barr, measles, mumps, varicella zoster and rubella viruses (EMMRZ) was recently presented, which may aid in the diagnosis of multiple sclerosis (MS). The aim of this study was to validate and extend the EMMRZ panel. Various candidates, such as Cytomegalovirus and John Cunningham virus were analysed in relapsing-remitting MS (RRMS) and optic neuritis (ON) samples by enzyme-linked immunosorbent assay. IgG levels were elevated in RRMS samples and correlations were found between serum and cerebrospinal fluid levels. Cohort-dependent optimized panels were obtained for RRMS and ON, which obtained the highest sensitivity when combined with the status of oligoclonal bands.

AB - An antigen panel consisting of Epstein-Barr, measles, mumps, varicella zoster and rubella viruses (EMMRZ) was recently presented, which may aid in the diagnosis of multiple sclerosis (MS). The aim of this study was to validate and extend the EMMRZ panel. Various candidates, such as Cytomegalovirus and John Cunningham virus were analysed in relapsing-remitting MS (RRMS) and optic neuritis (ON) samples by enzyme-linked immunosorbent assay. IgG levels were elevated in RRMS samples and correlations were found between serum and cerebrospinal fluid levels. Cohort-dependent optimized panels were obtained for RRMS and ON, which obtained the highest sensitivity when combined with the status of oligoclonal bands.

UR - http://www.scopus.com/inward/record.url?scp=85147858594&partnerID=8YFLogxK

U2 - 10.1016/j.imlet.2023.02.003

DO - 10.1016/j.imlet.2023.02.003

M3 - Journal article

C2 - 36764611

SN - 0165-2478

VL - 254

SP - 54

EP - 64

JO - Immunology Letters

JF - Immunology Letters

ER -

Antibodies to expanded virus antigen panels show elevated diagnostic sensitivities in multiple sclerosis and optic neuritis

Abstract

Access to Document

Other files and links

Fingerprint

Cite this