Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Antibodies to Epstein-Barr virus and neurotropic viruses in multiple sclerosis and optic neuritis

Research output: Contribution to journalJournal articleResearchpeer-review

  1. MAIT cell subtypes in multiple sclerosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Perfluorinated substances, risk factors for multiple sclerosis and cellular immune activation

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. B cells from patients with multiple sclerosis have a pathogenic phenotype and increased LTα and TGFβ1 response

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Inflammatory markers of CHMP2B-mediated frontotemporal dementia

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Association between Mental Disorders and Subsequent Medical Conditions

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Functional-structural assessment of the optic pathways in patients with optic neuritis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Association Between Neurological Disorders and Death by Suicide in Denmark

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Antibody indices to Measles, Mumps, Varicella Zoster (MRZ) are of diagnostic value in multiple sclerosis (MS). Here, we have investigated, if this panel could be extended to increase diagnostic value. Samples from relapsing-remitting (RR) MS and optic neuritis (ON) patients were tested for reactivity to antigens from Epstein-Barr, Varicella Zoster, Measles, Mumps and Rubella (EMMRZ) viruses. Increased IgG levels in serum and cerebrospinal fluid (CSF) were found in RRMS patients, along with a significant correlation between serum and CSF. The sensitivity of the EMMRZ panel was increased approximately 40% compared to the MRZ panel, suggesting that the EMMRZ panel may be useful in MS and ON diagnostics.

Original languageEnglish
Article number577314
JournalJournal of Neuroimmunology
Volume346
Pages (from-to)577314
ISSN0165-5728
DOIs
Publication statusPublished - 2020

    Research areas

  • Epstein Barr virus, Multiple sclerosis, Neurotrophic virus, Optic neuritis, Virus antigens

ID: 60407158