Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Antibiotic therapy for stable non-CF bronchiectasis in adults - A systematic review

Research output: Contribution to journalReviewResearchpeer-review

DOI

  1. COPD patients prescribed inhaled corticosteroid in general practice: Based on disease characteristics according to guidelines?

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Predictors of accelerated FEV1 decline in adults with airflow limitation-Findings from the Health2006 cohort

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Predictors of COPD in symptomatic smokers and ex-smokers seen in primary care

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Oral prednisolone for 4 days does not increase exercise tolerance in men with COPD

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Next-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases

    Research output: Contribution to journalReviewResearchpeer-review

  2. COPD patients prescribed inhaled corticosteroid in general practice: Based on disease characteristics according to guidelines?

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Female asthma and atopy - impact on fertility: a systematic review

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Predictors of accelerated FEV1 decline in adults with airflow limitation-Findings from the Health2006 cohort

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

To provide an update on efficacy and safety of antibiotic treatments for stable non-cystic fibrosis (CF) bronchiectasis (BE). Systematic review based on the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines was done. Twenty-six studies (1.898 patients) fulfilled the inclusion criteria. Studies of inhaled tobramycin have revealed conflicting results regarding quality of life (QoL), exacerbations and admissions, but may result in sputum cultures negative for Pseudomonas aeruginosa, whereas studies investigating the effect of inhaled gentamycin have shown positive effects on sputum bacterial density, decrease in sputum cultures positive for P. aeruginosa, QoL and exacerbation rate, but no improvement in forced expiratory volume in first second (FEV1). Oral azithromycin can reduce exacerbations, together with minor improvements in QoL and FEV1 Furthermore, oral erythromycin reduces exacerbations, but has no effect on lung function, symptoms or QoL. Inhaled ciprofloxacin may reduce P. aeruginosa in sputum cultures, but without changes in lung function, exacerbations or QoL. Although with limited evidence, inhaled colistin may have effects on P. aeruginosa density, exacerbations and QoL, whereas studies on aztreonam revealed no significant clinical improvements in the outcomes of interest, including exacerbation rate. Adverse events, including bronchospasm, have been reported in association with tobramycin and aztreonam. Several antibiotic treatment regimens have been shown to improve QoL and exacerbation rate, whereas findings regarding sputum production, lung function and admissions have been conflicting. Evidence-based treatment algorithms for antibiotic treatment of stable non-CF BE will have to await large-scale, long-term controlled studies.

Original languageEnglish
JournalChronic Respiratory Disease
Volume14
Issue number2
Pages (from-to)174-186
ISSN1479-9723
DOIs
Publication statusPublished - 2017

ID: 48349860