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Antagonism of the interleukin 4 receptor α promotes TH 1-signalling among T cells from patients with atopic dermatitis after stimulation

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Atopic dermatitis (AD) is a chronic and relapsing inflammatory skin disease. Molecular characterization of AD shows an underlying inflammation with tissue infiltration of T helper (TH ) 2 cells and increased IL-4 and IL-13. The multifaceted roles of IL-4 and IL-13 in allergic disease development make IL-4Rα an attractive target for treatment strategies, and a neutralizing monoclonal antibody which antagonizes the effects of both IL-4 and IL-13 by blocking the interaction site found in the IL-4 receptor subunit α (IL-4Rα) has been successfully used to treat patients with moderate-to-severe AD. To elucidate the effects of IL-4Rα blockade on the cellular level, we used flow cytometry to examine cytokine production after antigen stimulation in human T cells from patients with AD (n = 12) and healthy controls (n = 6). The cells were stimulated with and without a neutralizing monoclonal antibody against IL-4Rα. Our results indicate that blocking IL-4Rα prohibits IL-4 signalling and IL-13 signalling and thereby TH 2 differentiation followed by an upregulation of interferon-γ-producing cells.

Original languageEnglish
JournalScandinavian Journal of Immunology
Volume91
Issue number1
Pages (from-to)e12835
ISSN0300-9475
DOIs
Publication statusPublished - Jan 2020

    Research areas

  • Adult, Biomarkers, Cytokines/metabolism, Dermatitis, Atopic/immunology, Female, Humans, Immunoglobulin E/blood, Interleukin-4 Receptor alpha Subunit/antagonists & inhibitors, Leukocytes, Mononuclear/immunology, Male, Middle Aged, Signal Transduction, T-Lymphocyte Subsets/immunology, Th1 Cells/immunology, Young Adult

ID: 58983207