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Angiotensin-converting enzyme: an indicator of bleomycin-induced pulmonary toxicity in humans?

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  1. "Risk of de novo or secondary cancer after solid organ or allogeneic haematopoietic stem cell transplantation"

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  2. A revision of the Tokuhashi revised score improves the prognostic ability in patients with metastatic spinal cord compression

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  1. Gonocyte transformation in congenital undescended testes: what is the role of inhibin-B in cell death?

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  2. Xeno-Free Propagation of Spermatogonial Stem Cells from Infant Boys

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  3. Propagation of Spermatogonial Stem Cell-Like Cells From Infant Boys

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  4. Sertoli Cell Number Correlates with Serum Inhibin B in Infant Cryptorchid Boys

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  5. Successful performance of pediatric renography does not require sedation

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In order to evaluate bleomycin-associated lung damage in humans, lung function parameters and serum levels of the endothelial-bound angiotensin-converting enzyme (ACE) were determined by serial measurements in 11 patients who were treated for testicular cancer. None developed clinical or radiological evidence of pulmonary damage. While the static and dynamic lung function parameters were unchanged, carbon monoxide diffusion capacity (DLCO) decreased significantly (P less than 0.01) during a total of 126 days of pulsed regimen, indicating damage to the alveolar-endothelial membrane. S-ACE was unchanged within each treatment course but increased significantly (P less than 0.05) from the initial value to the last treatment course. Two months after cessation of treatment S-ACE returned to pretreatment values. Although the changes were modest they might mirror treatment-associated endothelial damage.

Original languageEnglish
JournalEuropean journal of cancer & clinical oncology
Volume20
Issue number11
Pages (from-to)1405-8
Number of pages4
ISSN0277-5379
Publication statusPublished - Nov 1984

    Research areas

  • Adolescent, Adult, Antineoplastic Combined Chemotherapy Protocols, Bleomycin, Cisplatin, Humans, Lung Diseases, Male, Peptidyl-Dipeptidase A, Respiratory Function Tests, Teratoma, Testicular Neoplasms, Time Factors, Vinblastine

ID: 46506209