Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Angiotensin II receptor blockers are safe in patients with prior angioedema related to angiotensin-converting enzyme inhibitors - a nationwide registry-based cohort study

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Coffee intake protects against symptomatic gallstone disease in the general population: a Mendelian randomization study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Women Living with HIV in high-income settings and Breastfeeding

    Research output: Contribution to journalReviewResearchpeer-review

  3. Effectiveness of maternal immunization with trivalent inactivated influenza vaccine in pregnant women and their infants

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Phenotypic and genotypic differences between Indian and Scandinavian women with gestational diabetes mellitus

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Biofilm formation - what we can learn from recent developments

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Ciliary Localization of the Intraflagellar Transport Protein IFT88 Is Disrupted in Cystic Fibrosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Primary ciliary dyskinesia patients have the same P. aeruginosa clone in sinuses and lungs

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Dynamic soft tissue changes in the orbit after a blowout fracture

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Incidence and survival of hypopharyngeal cancer: a Danish Nation-Wide Study from 1980 to 2014

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: It has long been suggested that angiotensin-converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (AT2s) have some degree of 'cross-reactivity' in causing angioedema. Therefore, caution has been advised when switching patients with ACEi-related angioedema to an AT2.

OBJECTIVES: To clarify whether AT2s can be used safely in patients with a history of angioedema during ACEi treatment and to estimate the incidence rate of angioedema in patients subsequently treated with other antihypertensive drugs (beta-adrenergic blockers, calcium channel blockers, thiazides and analogues) or no antihypertensives.

METHODS: This is a nationwide retrospective registry-based cohort study of the Danish population during the period 1994 to 2016, and it uses Danish health registries. Propensity score adjusted and conventional proportional hazards regression models have been employed.

RESULTS: A total of 1 106 024 ACEi users were identified. In total, 5 507 (0.5%) of these patients had experienced angioedema during ACEi treatment and were included in the study. The highest risk of angioedema recurrence was associated with continued ACEi use at an adjusted hazard ratio of 1.45 (95% CI, 1.19 to 1.78). An inverse association was found between AT2s and angioedema (adjusted hazard ratio, 0.39; 95% CI, 0.30 to 0.51) compared with other antihypertensives (adjusted hazard ratios, 0.77 to 0.97).

CONCLUSIONS: Compared with other antihypertensive drugs, AT2s do not increase the incidence of angioedema in patients with previous ACEi-related angioedema.

Original languageEnglish
JournalJournal of Internal Medicine
Volume285
Issue number5
Pages (from-to)553-561
Number of pages9
ISSN0954-6820
DOIs
Publication statusPublished - 1 May 2019

    Research areas

  • Angioedema, angiotensin-converting enzyme, angiotensins, hypertension, therapeutics

ID: 56612626