Abstract
The angiotensin II-induced vasodilatation was evaluated in rat middle cerebral artery, especially regarding endothelium-derived hyperpolarising factor (EDHF), by use of a pressurised arteriograph. The angiotensin II dilatation was partly antagonised by inhibitors of nitric oxide synthase and cyclo-oxygenase. The remaining dilatation was inhibited by the potassium channel blockers, charybdotoxin and apamin, providing direct evidence that angiotensin II induces EDHF-mediated dilatation in cerebral arteries. The angiotensin II dilatation was blocked by the angiotensin AT1 and AT2 receptor blockers candesartan and PD 123319. Both angiotensin AT1 and AT2 receptors were detected on the endothelium by immunohistochemistry.
| Original language | English |
|---|---|
| Journal | European Journal of Pharmacology |
| Volume | 531 |
| Issue number | 1-3 |
| Pages (from-to) | 259-63 |
| Number of pages | 5 |
| ISSN | 0014-2999 |
| DOIs | |
| Publication status | Published - 15 Feb 2006 |
| Externally published | Yes |
Keywords
- Adenosine Triphosphate
- Angiotensin II
- Angiotensin II Type 1 Receptor Blockers
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
- Apamin
- Benzimidazoles
- Biological Factors
- Cerebral Arteries
- Charybdotoxin
- Dose-Response Relationship, Drug
- Endothelium, Vascular
- Enzyme Inhibitors
- Imidazoles
- In Vitro Techniques
- Indomethacin
- Male
- Neurotoxins
- Nitric Oxide Synthase
- Nitroarginine
- Pyridines
- Rats
- Rats, Sprague-Dawley
- Serotonin
- Tetrazoles
- Vasoconstriction
- Vasoconstrictor Agents
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