Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Angiogenic and inflammatory biomarkers for screening and follow-up in patients with pulmonary arterial hypertension

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Epigenome- and Transcriptome-wide Changes in Muscle Stem Cells from Low Birth Weight Men

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Proteomics-Based Comparative Mapping of the Secretomes of Human Brown and White Adipocytes Reveals EPDR1 as a Novel Batokine

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Diverse repertoire of human adipocyte subtypes develops from transcriptionally distinct mesenchymal progenitor cells

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Dysregulated autophagy in muscle precursor cells from humans with type 2 diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

OBJECTIVE: To identify circulating angiogenic and inflammatory biomarkers with potential in screening for pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc), and in early diagnosis and determination of treatment response in PAH.

METHOD: Plasma samples were taken at the time of PAH diagnosis and at treatment follow-up after a median (interquartile range) of 4 months (3-9.8 months) in idiopathic (n = 9) and SSc-associated PAH (n = 11). In patients with SSc-associated PAH, plasma samples had also been gathered a median of 2 years (0.8-3 years) before PAH diagnosis (n = 10). Additional plasma samples were retrieved at two time-points separated by a median of 12 years (10-13 years) from SSc patients who did not develop PAH (n = 10) and from controls (n = 8). Angiogenic and inflammatory biomarkers were analysed by multiplex immunoassays.

RESULTS: Plasma levels of placenta growth factor (PlGF), soluble vascular endothelial growth factor receptor-1 (sVEGFR-1), and tumour necrosis factor-α (TNF-α) were higher (p < 0.05) in SSc patients who later developed PAH than in those who did not. Plasma vascular endothelial growth factor (VEGF)-D increased (p < 0.05) in SSc patients as PAH developed. Plasma levels of PlGF, VEGF-A, VEGF-D, sVEGFR-1, interleukin-6, and TNF-α were higher (p < 0.05) in PAH than controls. There were no significant differences in circulating biomarkers between idiopathic and SSc-associated PAH. Plasma sVEGFR-1 decreased (p < 0.05) after initiating PAH-targeted treatments.

CONCLUSIONS: Plasma levels of PlGF, sVEGFR-1, TNF-α, and VEGF-D have potential in screening for SSc-associated PAH. Plasma sVEGFR-1 may be a biomarker of treatment response.

Original languageEnglish
JournalScandinavian Journal of Rheumatology
Volume47
Issue number4
Pages (from-to)319-324
Number of pages6
ISSN0300-9742
DOIs
Publication statusPublished - Jul 2018

    Research areas

  • Aftercare, Aged, Biomarkers, Case-Control Studies, Female, Humans, Hypertension, Pulmonary/blood, Inflammation/immunology, Interleukin-6/immunology, Male, Mass Screening, Middle Aged, Natriuretic Peptide, Brain/blood, Neovascularization, Pathologic/blood, Peptide Fragments/blood, Placenta Growth Factor/blood, Scleroderma, Systemic/blood, Tumor Necrosis Factor-alpha/immunology, Vascular Endothelial Growth Factor A/blood, Vascular Endothelial Growth Factor D/blood, Vascular Endothelial Growth Factor Receptor-1/blood, Vascular Resistance, Walk Test

ID: 56586255