Ancient genomes from Iceland reveal the making of a human population

S Sunna Ebenesersdóttir; Marcela Sandoval-Velasco; Ellen D Gunnarsdóttir; Anuradha Jagadeesan; Valdís B Guðmundsdóttir; Elísabet L Thordardóttir; Margrét S Einarsdóttir; Kristjan H S Moore; Ásgeir Sigurðsson; Droplaug N Magnúsdóttir; Hákon Jónsson; Steinunn Snorradóttir; Eivind Hovig; Pål Møller; Ingrid Kockum; Tomas Olsson; Lars Alfredsson; Thomas F Hansen; Thomas Werge; Gianpiero L Cavalleri; Edmund Gilbert; Carles Lalueza-Fox; Joe W Walser; Steinunn Kristjánsdóttir; Shyam Gopalakrishnan; Lilja Árnadóttir; Ólafur Þ Magnússon; M Thomas P Gilbert; Kári Stefánsson; Agnar Helgason

doi:10.1126/science.aar2625

Ancient genomes from Iceland reveal the making of a human population

S Sunna Ebenesersdóttir, Marcela Sandoval-Velasco, Ellen D Gunnarsdóttir, Anuradha Jagadeesan, Valdís B Guðmundsdóttir, Elísabet L Thordardóttir, Margrét S Einarsdóttir, Kristjan H S Moore, Ásgeir Sigurðsson, Droplaug N Magnúsdóttir, Hákon Jónsson, Steinunn Snorradóttir, Eivind Hovig, Pål Møller, Ingrid Kockum, Tomas Olsson, Lars Alfredsson, Thomas F Hansen, Thomas Werge, Gianpiero L CavalleriEdmund Gilbert, Carles Lalueza-Fox, Joe W Walser, Steinunn Kristjánsdóttir, Shyam Gopalakrishnan, Lilja Árnadóttir, Ólafur Þ Magnússon, M Thomas P Gilbert, Kári Stefánsson, Agnar Helgason

77 Citations (Scopus)

Abstract

Opportunities to directly study the founding of a human population and its subsequent evolutionary history are rare. Using genome sequence data from 27 ancient Icelanders, we demonstrate that they are a combination of Norse, Gaelic, and admixed individuals. We further show that these ancient Icelanders are markedly more similar to their source populations in Scandinavia and the British-Irish Isles than to contemporary Icelanders, who have been shaped by 1100 years of extensive genetic drift. Finally, we report evidence of unequal contributions from the ancient founders to the contemporary Icelandic gene pool. These results provide detailed insights into the making of a human population that has proven extraordinarily useful for the discovery of genotype-phenotype associations.

Original language	English
Journal	Science
Volume	360
Issue number	6392
Pages (from-to)	1028-1032
Number of pages	5
ISSN	0036-8075
DOIs	https://doi.org/10.1126/science.aar2625
Publication status	Published - 1 Jun 2018

Keywords

Biological Evolution
DNA, Ancient
Female
Founder Effect
Gene Pool
Genetic Drift
Genome, Human
Genotype
Humans
Iceland
Male
Phenotype
Population/genetics

Access to Document

10.1126/science.aar2625

Cite this

Ebenesersdóttir, S. S., Sandoval-Velasco, M., Gunnarsdóttir, E. D., Jagadeesan, A., Guðmundsdóttir, V. B., Thordardóttir, E. L., Einarsdóttir, M. S., Moore, K. H. S., Sigurðsson, Á., Magnúsdóttir, D. N., Jónsson, H., Snorradóttir, S., Hovig, E., Møller, P., Kockum, I., Olsson, T., Alfredsson, L., Hansen, T. F., Werge, T., ... Helgason, A. (2018). Ancient genomes from Iceland reveal the making of a human population. Science, 360(6392), 1028-1032. https://doi.org/10.1126/science.aar2625

Ebenesersdóttir, SS, Sandoval-Velasco, M, Gunnarsdóttir, ED, Jagadeesan, A, Guðmundsdóttir, VB, Thordardóttir, EL, Einarsdóttir, MS, Moore, KHS, Sigurðsson, Á, Magnúsdóttir, DN, Jónsson, H, Snorradóttir, S, Hovig, E, Møller, P, Kockum, I, Olsson, T, Alfredsson, L, Hansen, TF , Werge, T, Cavalleri, GL, Gilbert, E, Lalueza-Fox, C, Walser, JW, Kristjánsdóttir, S, Gopalakrishnan, S, Árnadóttir, L, Magnússon, ÓÞ, Gilbert, MTP, Stefánsson, K & Helgason, A 2018, 'Ancient genomes from Iceland reveal the making of a human population', Science, vol. 360, no. 6392, pp. 1028-1032. https://doi.org/10.1126/science.aar2625

@article{d83ee2a312a24688856de7c20dee23c1,

title = "Ancient genomes from Iceland reveal the making of a human population",

abstract = "Opportunities to directly study the founding of a human population and its subsequent evolutionary history are rare. Using genome sequence data from 27 ancient Icelanders, we demonstrate that they are a combination of Norse, Gaelic, and admixed individuals. We further show that these ancient Icelanders are markedly more similar to their source populations in Scandinavia and the British-Irish Isles than to contemporary Icelanders, who have been shaped by 1100 years of extensive genetic drift. Finally, we report evidence of unequal contributions from the ancient founders to the contemporary Icelandic gene pool. These results provide detailed insights into the making of a human population that has proven extraordinarily useful for the discovery of genotype-phenotype associations.",

keywords = "Biological Evolution, DNA, Ancient, Female, Founder Effect, Gene Pool, Genetic Drift, Genome, Human, Genotype, Humans, Iceland, Male, Phenotype, Population/genetics",

author = "Ebenesersd{\'o}ttir, \{S Sunna\} and Marcela Sandoval-Velasco and Gunnarsd{\'o}ttir, \{Ellen D\} and Anuradha Jagadeesan and Gu{\dh}mundsd{\'o}ttir, \{Vald{\'i}s B\} and Thordard{\'o}ttir, \{El{\'i}sabet L\} and Einarsd{\'o}ttir, \{Margr{\'e}t S\} and Moore, \{Kristjan H S\} and {\'A}sgeir Sigur{\dh}sson and Magn{\'u}sd{\'o}ttir, \{Droplaug N\} and H{\'a}kon J{\'o}nsson and Steinunn Snorrad{\'o}ttir and Eivind Hovig and P{\aa}l M{\o}ller and Ingrid Kockum and Tomas Olsson and Lars Alfredsson and Hansen, \{Thomas F\} and Thomas Werge and Cavalleri, \{Gianpiero L\} and Edmund Gilbert and Carles Lalueza-Fox and Walser, \{Joe W\} and Steinunn Kristj{\'a}nsd{\'o}ttir and Shyam Gopalakrishnan and Lilja {\'A}rnad{\'o}ttir and Magn{\'u}sson, \{{\'O}lafur {\TH}\} and Gilbert, \{M Thomas P\} and K{\'a}ri Stef{\'a}nsson and Agnar Helgason",

note = "Copyright {\textcopyright} 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.",

year = "2018",

month = jun,

day = "1",

doi = "10.1126/science.aar2625",

language = "English",

volume = "360",

pages = "1028--1032",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6392",

}

TY - JOUR

T1 - Ancient genomes from Iceland reveal the making of a human population

AU - Ebenesersdóttir, S Sunna

AU - Sandoval-Velasco, Marcela

AU - Gunnarsdóttir, Ellen D

AU - Jagadeesan, Anuradha

AU - Guðmundsdóttir, Valdís B

AU - Thordardóttir, Elísabet L

AU - Einarsdóttir, Margrét S

AU - Moore, Kristjan H S

AU - Sigurðsson, Ásgeir

AU - Magnúsdóttir, Droplaug N

AU - Jónsson, Hákon

AU - Snorradóttir, Steinunn

AU - Hovig, Eivind

AU - Møller, Pål

AU - Kockum, Ingrid

AU - Olsson, Tomas

AU - Alfredsson, Lars

AU - Hansen, Thomas F

AU - Werge, Thomas

AU - Cavalleri, Gianpiero L

AU - Gilbert, Edmund

AU - Lalueza-Fox, Carles

AU - Walser, Joe W

AU - Kristjánsdóttir, Steinunn

AU - Gopalakrishnan, Shyam

AU - Árnadóttir, Lilja

AU - Magnússon, Ólafur Þ

AU - Gilbert, M Thomas P

AU - Stefánsson, Kári

AU - Helgason, Agnar

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Opportunities to directly study the founding of a human population and its subsequent evolutionary history are rare. Using genome sequence data from 27 ancient Icelanders, we demonstrate that they are a combination of Norse, Gaelic, and admixed individuals. We further show that these ancient Icelanders are markedly more similar to their source populations in Scandinavia and the British-Irish Isles than to contemporary Icelanders, who have been shaped by 1100 years of extensive genetic drift. Finally, we report evidence of unequal contributions from the ancient founders to the contemporary Icelandic gene pool. These results provide detailed insights into the making of a human population that has proven extraordinarily useful for the discovery of genotype-phenotype associations.

AB - Opportunities to directly study the founding of a human population and its subsequent evolutionary history are rare. Using genome sequence data from 27 ancient Icelanders, we demonstrate that they are a combination of Norse, Gaelic, and admixed individuals. We further show that these ancient Icelanders are markedly more similar to their source populations in Scandinavia and the British-Irish Isles than to contemporary Icelanders, who have been shaped by 1100 years of extensive genetic drift. Finally, we report evidence of unequal contributions from the ancient founders to the contemporary Icelandic gene pool. These results provide detailed insights into the making of a human population that has proven extraordinarily useful for the discovery of genotype-phenotype associations.

KW - Biological Evolution

KW - DNA, Ancient

KW - Female

KW - Founder Effect

KW - Gene Pool

KW - Genetic Drift

KW - Genome, Human

KW - Genotype

KW - Humans

KW - Iceland

KW - Male

KW - Phenotype

KW - Population/genetics

UR - https://www.scopus.com/pages/publications/85048183500

U2 - 10.1126/science.aar2625

DO - 10.1126/science.aar2625

M3 - Journal article

C2 - 29853688

SN - 0036-8075

VL - 360

SP - 1028

EP - 1032

JO - Science

JF - Science

IS - 6392

ER -

Ancient genomes from Iceland reveal the making of a human population

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this