Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

AnAnkle Trial study protocol: a randomised trial comparing pain profiles after peripheral nerve block or spinal anaesthesia for ankle fracture surgery

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Outcomes reported on the management of COPD exacerbations: a systematic survey of randomised controlled trials

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Fast-track pneumonia pathway focusing on early progressive mobilisation: a clinical feasibility study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Feasibility of portable continuous laryngoscopy during exercise testing

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. The clinical implication of the association between hypoxaemia and postoperative troponin I: a reply

    Research output: Contribution to journalComment/debateResearchpeer-review

View graph of relations

INTRODUCTION: Ankle fracture surgery is a common procedure, but the influence of anaesthesia choice on postoperative pain and quality of recovery is poorly understood. Some authors suggest a benefit of peripheral nerve block (PNB) in elective procedures, but the different pain profile following acute fracture surgery and the rebound pain on cessation of the PNB both remain unexplored. We present an ongoing randomised study aiming to compare primary PNB anaesthesia with spinal anaesthesia for ankle fracture surgery regarding postoperative pain profiles and quality of recovery.

METHODS AND ANALYSIS: AnAnkle Trial is a randomised, dual-centre, open-label, blinded analysis trial of 150 adult patients undergoing primary internal fixation of an ankle fracture. Main exclusion criteria are habitual opioid use, impaired pain sensation, other painful injuries or cognitive impairment. The intervention is ultrasound-guided popliteal sciatic (20 mL) and saphenal nerve (8 mL) PNB with ropivacaine 7.5 mg/mL, and controls receive spinal anaesthesia (2 mL) with hyperbaric bupivacaine 5 mg/mL. Postoperatively all receive paracetamol, ibuprofen and patient-controlled intravenous morphine on demand. Morphine consumption and pain scores are registered in the first 27 hours and reported as an integrated pain score as the primary endpoint. Pain score intervals are 3 hours and we will use the area under curve to get a longitudinal measure of pain. Secondary outcomes include rebound pain on cessation of anaesthesia, opioid side effects (Opioid-Related Symptom Distress Scale), quality of recovery (Danish Quality of Recovery-15 score) and pain scores and medication days 1-7 (diary).

ETHICS AND DISSEMINATION: The study has been approved by the Regional Ethics Committees in the Capital Region of Denmark, the Danish Data Protection Agency and the Danish Health and Medical Authority. We will publish the results in international peer-reviewed medical journals.

TRIAL REGISTRATION NUMBER: AnAnkle Trial is registered in the European Clinical Trials Database (EudraCT 2015-001108-76).

Original languageEnglish
JournalB M J Open
Volume7
Issue number5
Pages (from-to)e016001
ISSN2044-6055
DOIs
Publication statusPublished - 2 Jun 2017

    Research areas

  • Journal Article

ID: 51616784