Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Analytical considerations and plans to standardize or harmonize assays for the reference bone turnover markers PINP and β-CTX in blood

Research output: Contribution to journalJournal articlepeer-review

  1. Analysis of HOXA9 methylated ctDNA in ovarian cancer using sense-antisense measurement

    Research output: Contribution to journalJournal articlepeer-review

  2. Citrullination of fibrinogen by peptidylarginine deiminase 2 impairs fibrin clot structure

    Research output: Contribution to journalJournal articlepeer-review

  1. Circadian rhythm of markers of bone turnover in patients with chronic kidney disease

    Research output: Contribution to journalJournal articlepeer-review

  2. The Arg82Cys polymorphism of the protein Nepmucin implies a role in HDL metabolism

    Research output: Contribution to journalJournal articlepeer-review

  3. Administration of whey protein complexed vitamin D3 to vitamin D3-deficient growing Sprague-Dawley rats

    Research output: Contribution to journalJournal articlepeer-review

  4. Bone involvement in patients with spondyloarthropathies

    Research output: Contribution to journalReviewpeer-review

  • Harjit P Bhattoa
  • Etienne Cavalier
  • Richard Eastell
  • Annemieke C Heijboer
  • Niklas R Jørgensen
  • Konstantinos Makris
  • Candice Z Ulmer
  • John A Kanis
  • Cyrus Cooper
  • Stuart L Silverman
  • Samuel D Vasikaran
  • IFCC-IOF Committee for Bone Metabolism
View graph of relations

Procollagen type I N-propeptide (PINP) and the C-terminal telopeptide of type I collagen (β-CTX) in blood have been designated as reference bone turnover markers in osteoporosis by the International Osteoporosis Foundation (IOF) and International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). The IFCC Committee on Bone Metabolism (C-BM) has examined current commercial assays and performed a multicentre study to examine the agreement between assays for PINP and β-CTX in serum and plasma. The results of these studies will inform our work towards the harmonization of PINP assays and the standardization of β-CTX assays in blood, with the development of common calibrators and reference measurement procedures in collaboration with the reagent manufacturing industry. Successful achievement of these goals will help develop universally acceptable practice guidelines for the management of osteoporosis with the inclusion of common reference intervals and treatment targets for PINP and β-CTX.

Original languageEnglish
JournalClinica chimica acta; international journal of clinical chemistry
Volume515
Pages (from-to)16-20
Number of pages5
ISSN0009-8981
DOIs
Publication statusPublished - Apr 2021

    Research areas

  • Bone formation, Bone resorption, Bone turnover markers, C-terminal telopeptide of type I collagen, Harmonization, PINP, Procollagen type I N-propeptide, Standardization, β-CTX

ID: 64127535