Analysis of over 10,000 Cases finds no association between previously reported candidate polymorphisms and ovarian cancer outcome

Kristin L White; Robert A Vierkant; Zachary C Fogarty; Bridget Charbonneau; Matthew S Block; Paul D P Pharoah; Georgia Chenevix-Trench; Mary Anne Rossing; Daniel W Cramer; Celeste Leigh Pearce; Joellen M Schildkraut; Usha Menon; Susanne Kruger Kjaer; Douglas A Levine; Jacek Gronwald; Hoda Anton Culver; Alice S Whittemore; Beth Y Karlan; Diether Lambrechts; Nicolas Wentzensen; Jolanta Kupryjanczyk; Jenny Chang-Claude; Elisa V Bandera; Estrid Hogdall; Florian Heitz; Stanley B Kaye; Peter A Fasching; Ian Campbell; Marc T Goodman; Tanja Pejovic; Yukie Bean; Galina Lurie; Diana Eccles; Alexander Hein; Matthias W Beckmann; Arif B Ekici; James Paul; Robert James (Jim) Brown; James M Flanagan; Philipp Harter; Andreas du Bois; Ira Schwaab; Claus K Hogdall; Lene Lundvall; Sara H Olson; Irene Orlow; Lisa E Paddock; Anja Rudolph; Ursula Eilber; Allan Jensen; for AOCS/ACS group;

doi:10.1158/1055-9965.EPI-13-0028

Analysis of over 10,000 Cases finds no association between previously reported candidate polymorphisms and ovarian cancer outcome

Kristin L White, Robert A Vierkant, Zachary C Fogarty, Bridget Charbonneau, Matthew S Block, Paul D P Pharoah, Georgia Chenevix-Trench, Mary Anne Rossing, Daniel W Cramer, Celeste Leigh Pearce, Joellen M Schildkraut, Usha Menon, Susanne Kruger Kjaer, Douglas A Levine, Jacek Gronwald, Hoda Anton Culver, Alice S Whittemore, Beth Y Karlan, Diether Lambrechts, Nicolas WentzensenJolanta Kupryjanczyk, Jenny Chang-Claude, Elisa V Bandera, Estrid Hogdall, Florian Heitz, Stanley B Kaye, Peter A Fasching, Ian Campbell, Marc T Goodman, Tanja Pejovic, Yukie Bean, Galina Lurie, Diana Eccles, Alexander Hein, Matthias W Beckmann, Arif B Ekici, James Paul, Robert James (Jim) Brown, James M Flanagan, Philipp Harter, Andreas du Bois, Ira Schwaab, Claus K Hogdall, Lene Lundvall, Sara H Olson, Irene Orlow, Lisa E Paddock, Anja Rudolph, Ursula Eilber, Allan Jensen, for AOCS/ACS group;

Department of Pathology

19 Citations (Scopus)

Abstract

Ovarian cancer is a leading cause of cancer-related death among women. In an effort to understand contributors to disease outcome, we evaluated single-nucleotide polymorphisms (SNP) previously associated with ovarian cancer recurrence or survival, specifically in angiogenesis, inflammation, mitosis, and drug disposition genes.

Original language	English
Journal	Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Volume	22
Issue number	5
Pages (from-to)	987-92
Number of pages	6
ISSN	1055-9965
DOIs	https://doi.org/10.1158/1055-9965.EPI-13-0028
Publication status	Published - May 2013

Keywords

Female
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Humans
Ovarian Neoplasms
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Prognosis
Proportional Hazards Models
Survival Analysis

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http://cebp.aacrjournals.org/content/22/5/987.full.pdf+html

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White, K. L., Vierkant, R. A., Fogarty, Z. C., Charbonneau, B., Block, M. S., Pharoah, P. D. P., Chenevix-Trench, G., Rossing, M. A., Cramer, D. W., Pearce, C. L., Schildkraut, J. M., Menon, U., Kjaer, S. K., Levine, D. A., Gronwald, J., Culver, H. A., Whittemore, A. S., Karlan, B. Y., Lambrechts, D., ... for AOCS/ACS group; (2013). Analysis of over 10,000 Cases finds no association between previously reported candidate polymorphisms and ovarian cancer outcome. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 22(5), 987-92. https://doi.org/10.1158/1055-9965.EPI-13-0028

Analysis of over 10,000 Cases finds no association between previously reported candidate polymorphisms and ovarian cancer outcome. / White, Kristin L; Vierkant, Robert A; Fogarty, Zachary C et al.
In: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 22, No. 5, 05.2013, p. 987-92.

Research output: Contribution to journal › Journal article › Research › peer-review

White, KL, Vierkant, RA, Fogarty, ZC, Charbonneau, B, Block, MS, Pharoah, PDP, Chenevix-Trench, G, Rossing, MA, Cramer, DW, Pearce, CL, Schildkraut, JM, Menon, U, Kjaer, SK, Levine, DA, Gronwald, J, Culver, HA, Whittemore, AS, Karlan, BY, Lambrechts, D, Wentzensen, N, Kupryjanczyk, J, Chang-Claude, J, Bandera, EV, Hogdall, E, Heitz, F, Kaye, SB, Fasching, PA, Campbell, I, Goodman, MT, Pejovic, T, Bean, Y, Lurie, G, Eccles, D, Hein, A, Beckmann, MW, Ekici, AB, Paul, J, Brown, RJ, Flanagan, JM, Harter, P, du Bois, A, Schwaab, I, Hogdall, CK, Lundvall, L, Olson, SH, Orlow, I, Paddock, LE, Rudolph, A, Eilber, U, Jensen, A & for AOCS/ACS group; 2013, 'Analysis of over 10,000 Cases finds no association between previously reported candidate polymorphisms and ovarian cancer outcome', Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, vol. 22, no. 5, pp. 987-92. https://doi.org/10.1158/1055-9965.EPI-13-0028

White KL, Vierkant RA, Fogarty ZC, Charbonneau B, Block MS, Pharoah PDP et al. Analysis of over 10,000 Cases finds no association between previously reported candidate polymorphisms and ovarian cancer outcome. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2013 May;22(5):987-92. doi: 10.1158/1055-9965.EPI-13-0028

White, Kristin L ; Vierkant, Robert A ; Fogarty, Zachary C et al. / Analysis of over 10,000 Cases finds no association between previously reported candidate polymorphisms and ovarian cancer outcome. In: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2013 ; Vol. 22, No. 5. pp. 987-92.

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abstract = "Ovarian cancer is a leading cause of cancer-related death among women. In an effort to understand contributors to disease outcome, we evaluated single-nucleotide polymorphisms (SNP) previously associated with ovarian cancer recurrence or survival, specifically in angiogenesis, inflammation, mitosis, and drug disposition genes.",

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KW - Proportional Hazards Models

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Analysis of over 10,000 Cases finds no association between previously reported candidate polymorphisms and ovarian cancer outcome

Abstract

Keywords

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